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Development of an Atmospheric Plasma Applicator to Treat Chronic Wounds

Award Number: R44GM099207
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2011
PERIOD OF PERFORMANCE END DATE: 05/10/2017

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Development of an Atmospheric Plasma Applicator to Treat Chronic Wounds - DESCRIPTION (provided by applicant): Annually, 5 to 7 million Americans are treated for chronic wounds that arise from diabetes, lower extremity arterial disease, lower extremity venous disease, pressure ulcers, and traumatic injuries, including burns, demonstrating the need for new advanced technologies for treatment. Advanced Plasma Products will build upon its successful Phase I results and advance the development of the Atmospheric Plasma Wound Applicator (APWA) prototypes that inactivate biofilm without causing damage to surrounding tissues, thereby healing the wound. The prototype will be tested for its wound disinfecting capabilities with in vitro wound biofilm models of different clinically significant strains and polymicrobial biofilm. Penetration studies will be performed to evaluate the depth of plasma active species in tissue and mechanistic studies will evaluate the mechanism of inactivation of microbial cells by plasma treatment. We will demonstrate the therapeutic potential of atmospheric plasma to improve wound healing by the removal of microorganisms from the biofilm of splinted excisional wounds of normal and diabetic mice and the introduction of various gaseous nitrogen species. A second generation prototype will be built and tested in a clinical setting with equine lower limb wounds. Following this two year effort, APP will initiate FDA 510K regulatory approval process.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2014	ADVANCED PLASMA PRODUCTS, INC.	231 SAM RAYBURN PKWY	LENOIR CITY	TN	37771	LOUDON	USA	Biomedical Research and Research Training	000	3	5/24/2017	NON-COMPETING CONTINUATION	$0
2017	2014	ADVANCED PLASMA PRODUCTS, INC.	231 SAM RAYBURN PKWY	LENOIR CITY	TN	37771	LOUDON	USA	Biomedical Research and Research Training	001	3	6/20/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $0 )
2016	2014	ADVANCED PLASMA PRODUCTS INC	924 CORRIDOR PARK BOULEVARD	KNOXVILLE	TN	37932	KNOX	USA	Biomedical Research and Research Training	000	3	7/28/2016	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2014 ( Subtotal = $1,076,505 )
2014	2014	ADVANCED PLASMA PRODUCTS INC	924 CORRIDOR PARK BOULEVARD	KNOXVILLE	TN	37932	KNOX	USA	Biomedical Research and Research Training	000	3	9/3/2014	NON-COMPETING CONTINUATION	$1,076,505
														Subtotal = $1,076,505

Issue Date FY: 2013 ( Subtotal = $1,111,985 )
2013	2013	ADVANCED PLASMA PRODUCTS INC	924 CORRIDOR PARK BOULEVARD	KNOXVILLE	TN	37932	KNOX	USA	Biomedical Research and Research Training	000	2	8/29/2013	COMPETING CONTINUATION	$1,111,985
														Subtotal = $1,111,985

Grand Total All Awards = $2,188,490

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Development of an Atmospheric Plasma Applicator to Treat Chronic Wounds

Award Number: R44GM099207

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2011

PERIOD OF PERFORMANCE END DATE: 05/10/2017

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