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DEVICE FOR AUTOMATING ZEBRAFISH PROCESSING

Award Number: R44GM090598
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2011
PERIOD OF PERFORMANCE END DATE: 04/30/2013

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DEVICE FOR AUTOMATING ZEBRAFISH PROCESSING - DESCRIPTION (provided by applicant): Although conventional sample handling can be adapted for use with processing zebrafish, development of appropriate analytical tools has not kept pace with the increasing use of this animal model for compound screening. In this research, we propose to develop a device to automate zebrafish processing. Zebrafish embryos, which are permeable to small molecules, provide easy access for drug administration and vital dye staining. Small molecules, including peptides, dyes and drugs can be simply dissolved in fish water. Additional advantages include: their small size, easy maintenance and breeding, and high productivity. Use of zebrafish as an alternative animal model for drug screening can greatly accelerate the drug screening process, decrease costs, and provide more accurate results than cell-based assays. There are currently more than 300 core zebrafish aquaculture facilities (2/3 are in the US), and the number of satellite labs is increasing rapidly due to development of modular breeding racks. This market is highly concentrated and products can be sold using a small sales force or through distributors. PUBLIC HEALTH RELEVANCE: Zebrafish has been shown to be a predictive animal model for assessing compound safety, toxicity, and efficacy. Although conventional sample handling can be adapted for use with processing zebrafish, development of appropriate analytical tools has not kept pace with the increasing use of this animal model for compound screening. In this research, we propose to develop a device to automate zebrafish processing.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2012 ( Subtotal = $413,650 )
2012	2012	PHYLONIX PHARMACEUTICALS, INC	100 INMAN STREET SUITE 300	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Biomedical Research and Research Training	000	3	8/20/2012	NON-COMPETING CONTINUATION	$413,650
														Subtotal = $413,650

Issue Date FY: 2011 ( Subtotal = $412,645 )
2011	2011	PHYLONIX PHARMACEUTICALS, INC	100 INMAN STREET SUITE 300	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Biomedical Research and Research Training	000	2	4/15/2011	COMPETING CONTINUATION	$412,645
														Subtotal = $412,645

Grand Total All Awards = $826,295

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DEVICE FOR AUTOMATING ZEBRAFISH PROCESSING

Award Number: R44GM090598

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2011

PERIOD OF PERFORMANCE END DATE: 04/30/2013

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