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Comprehensive imaging and quantification of blood flow for investigating ocular diseases without additional contrast agent

Award Number: R44EY030812
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2019
PERIOD OF PERFORMANCE END DATE: 02/28/2025

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Comprehensive imaging and quantification of blood flow for investigating ocular diseases without additional contrast agent - Project Summary/Abstract Physical Sciences Inc. (PSI) in collaboration with New York University (NYU) School of Medicine proposes to develop a novel ophthalmic imaging platform for characterizing retinal morphology and monitoring ocular blood flow abnormalities. This platform will combine non-invasive measurements of retina/choroid structure and ocular blood flow based on optical coherence tomography (OCT) and wide- field semi-quantitative global flow visualization using line-scanning Doppler flowmetry (LSDF). The combination of these two imaging modalities within the same imaging platform enables comprehensive assessment of blood flow in the retina and choroid. This novel imaging platform will enable imaging studies in animals and human subjects with normal vision or with various retinal diseases. Prior PSI experience in developing advanced ophthalmic imaging systems coupled with our collaborators' expertise in Ophthalmology will be leveraged to ensure the successful outcome of this important R&D program. A feasibility study will be performed during the Phase I program by imaging normal and diseased rodent models using a benchtop instrument. A clinical prototype instrument will be manufactured and tested clinically in Phase II in the NYU population of patients to highlight hemodynamic retinal biomarkers. We choose to focus on diseases that are the leading causes of blindness including, age-related macular degeneration (AMD), diabetic retinopathy (DR), and glaucoma to demonstrate the clinical utility of our novel system. We will recruit healthy individuals to set a reference, and subjects with AMD, DR, and glaucoma at a wide range of disease severity. In all of these conditions, the ability to record in vivo blood flow will provide novel information that will open new diagnostic and treatment avenues.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$61,469 )
2025	2022	PHYSICAL SCIENCES INC.	20 NEW ENGLAND BUSINESS CENTER DR	ANDOVER	MA	01810	ESSEX	USA	Vision Research	000	3	7/2/2025	NON-COMPETING CONTINUATION	-$61,469
														Subtotal = -$61,469

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	PHYSICAL SCIENCES INC.	20 NEW ENGLAND BUSINESS CENTER DR	ANDOVER	MA	01810	ESSEX	USA	Vision Research	000	3	3/15/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $482,523 )
2022	2022	PHYSICAL SCIENCES INC.	20 NEW ENGLAND BUSINESS CTR DR	ANDOVER	MA	01810	ESSEX	USA	Vision Research	000	3	3/7/2022	NON-COMPETING CONTINUATION	$482,523
														Subtotal = $482,523

Issue Date FY: 2021 ( Subtotal = $678,314 )
2021	2021	PHYSICAL SCIENCES INC.	20 NEW ENGLAND BUSINESS CTR DR	ANDOVER	MA	01810	ESSEX	USA	Vision Research	002	2	4/1/2021	EXTENSION WITH OR WITHOUT FUNDS	$0
2021	2021	PHYSICAL SCIENCES INC.	20 NEW ENGLAND BUSINESS CTR DR	ANDOVER	MA	01810	ESSEX	USA	Vision Research	001	2	2/11/2021	EXTENSION WITH OR WITHOUT FUNDS	$678,314
2021	2019	PHYSICAL SCIENCES INC.	20 NEW ENGLAND BUSINESS CTR DR	ANDOVER	MA	01810	ESSEX	USA	Vision Research	000	1	12/8/2020	NEW	$0
														Subtotal = $678,314

Issue Date FY: 2019 ( Subtotal = $229,995 )
2019	2019	PHYSICAL SCIENCES INC.	20 NEW ENGLAND BUSINESS CTR DR	ANDOVER	MA	01810	ESSEX	USA	Vision Research	000	1	8/27/2019	NEW	$229,995
														Subtotal = $229,995

Grand Total All Awards = $1,329,363

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Comprehensive imaging and quantification of blood flow for investigating ocular diseases without additional contrast agent

Award Number: R44EY030812

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2019

PERIOD OF PERFORMANCE END DATE: 02/28/2025

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