| | | | | | | | | | | | | | | | |
| | |
 | Issue Date FY: 2025 ( Subtotal = $276,344 ) |
| | 2025 | 2025 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CENTER DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R43MH136847 | Fast multicolor confocal fluorescence imager for neural network mapping | 000 | 1 | NIH | 12/30/2024 | $314,113 |
| | 2025 | 2023 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CENTER DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R43GM148082 | Smart sensor for guiding safe delivery of anesthetic and pain drugs through epidurals | 000 | 1 | NIH | 4/2/2025 | -$4,431 |
| | 2025 | 2023 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CENTER DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R44MH116748 | Supplemental support for the development of high spatiotemporal resolution neuronal imager | 000 | 3 | NIH | 11/1/2024 | $0 |
| | 2025 | 2022 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CENTER DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R43GM148094 | Sensitive and spatially-selective quantification of oxygen in the headspace of pharmaceutical vials | 000 | 1 | NIH | 4/2/2025 | $0 |
| | 2025 | 2021 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CENTER DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R44CA240040 | Multimodal Optical Probe for Skin Cancer Detection and Therapy Guidance | 000 | 3 | NIH | 11/6/2024 | -$33,338 |
|
| Issue Date FY: 2024 ( Subtotal = $869,635 ) |
| | 2024 | 2024 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CENTER DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R43GM154541 | Virtual chromatographic cytometry for in-line biomanufacturing process analysis | 001 | 1 | NIH | 9/24/2024 | $0 |
| | 2024 | 2024 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CENTER DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R43ES036478 | High-Sensitivity Benzene Detector for Environmental Field Surveys | 000 | 1 | NIH | 6/3/2024 | $294,253 |
| | 2024 | 2024 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CENTER DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R43GM154541 | Virtual chromatographic cytometry for in-line biomanufacturing process analysis | 000 | 1 | NIH | 8/22/2024 | $302,417 |
| | 2024 | 2024 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CENTER DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R43MH126790 | Head-mounted, high-speed confocal imager for voltage-sensitive neuronal recording | 000 | 1 | NIH | 2/5/2024 | $300,837 |
| | 2024 | 2023 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CENTER DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R43GM148082 | Smart sensor for guiding safe delivery of anesthetic and pain drugs through epidurals | 001 | 1 | NIH | 2/21/2024 | $0 |
| | 2024 | 2023 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CENTER DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | U01FD007689 | Development and Experimental Verification of Fundamental Models to Enable Implementation of Microwave-Assisted Freeze Drying | 000 | 2 | FDA | 8/22/2024 | $0 |
| | 2024 | 2023 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CENTER DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | U01FD007689 | Development and Experimental Verification of Fundamental Models to Enable Implementation of Microwave-Assisted Freeze Drying | 000 | 2 | FDA | 8/22/2024 | $0 |
| | 2024 | 2023 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CENTER DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R44CA273961 | Intelligent Optical Probe for Guiding Core Needle Biopsy Procedures | 000 | 2 | NIH | 12/11/2023 | $0 |
| | 2024 | 2022 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CENTER DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R44CA250727 | Ultra-sensitive Singlet Oxygen Dosimeter for Skin Cancer Treatment and Prevention | 000 | 3 | NIH | 7/11/2024 | $0 |
| | 2024 | 2022 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CENTER DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R44EY030812 | Comprehensive imaging and quantification of blood flow for investigating ocular diseases without additional contrast agent | 000 | 3 | NIH | 3/15/2024 | $0 |
| | 2024 | 2022 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CENTER DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R43GM148082 | Smart sensor for guiding safe delivery of anesthetic and pain drugs through epidurals | 000 | 1 | NIH | 2/21/2024 | $0 |
| | 2024 | 2021 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CENTER DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R44OH011711 | Quantitative Methane Plume Imager for Localization and Flow Rate Estimation in Mines | 02 | 2 | CDC | 2/12/2024 | $0 |
| | 2024 | 2021 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CENTER DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R41AG073222 | Multi-modal cloud based system for detecting early signs of driver cognitive decline and/or high risk driving behaviors | 000 | 1 | NIH | 2/9/2024 | $0 |
| | 2024 | 2021 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CENTER DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R43EY032417 | Versatile Eye Tracking for Improved High-resolution Retinal Imaging | 000 | 1 | NIH | 10/25/2023 | $0 |
| | 2024 | 2021 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CENTER DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R43EB032676 | Smart Multi-grid Template for Focal Therapy of Prostate Cancer | 000 | 1 | NIH | 5/10/2024 | -$4,052 |
| | 2024 | 2021 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CENTER DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R43AG074744 | Multispectral cellular-level retinal imaging for early detection of Alzheimer’s disease | 000 | 1 | NIH | 2/9/2024 | $0 |
| | 2024 | 2021 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CENTER DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R43HL156359 | Electrohydraulic impactor for peripheral arterial occlusion management | 000 | 1 | NIH | 8/5/2024 | $0 |
| | 2024 | 2021 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CENTER DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R44OH011711 | Quantitative Methane Plume Imager for Localization and Flow Rate Estimation in Mines | 02 | 2 | CDC | 2/12/2024 | $0 |
| | 2024 | 2020 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CENTER DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R43HL154866 | Endoscopic Multifunctional Optical Coherence Tomography for Airway Tissue Injury Management | 000 | 1 | NIH | 3/1/2024 | -$402 |
| | 2024 | 2020 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CENTER DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R44CA224853 | Smart template for prostate biopsy guidance | 000 | 3 | NIH | 4/11/2024 | -$20,949 |
| | 2024 | 2020 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CENTER DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R44OH011711 | Quantitative Methane Plume Imager for Localization and Flow Rate Estimation in Mines | 02 | 2 | CDC | 2/12/2024 | -$2,470 |
|
| Issue Date FY: 2023 ( Subtotal = $7,468,540 ) (Continued on the next page) |
| | 2023 | 2023 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CTR DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R43GM150354 | Metabolic cytometry for in-line process analysis | 000 | 1 | NIH | 3/15/2023 | $286,171 |
| | 2023 | 2023 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CTR DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R44DE029631 | Advanced Intraoperative Imager for Nerve Identification | 001 | 3 | NIH | 3/7/2023 | $870,860 |
| | 2023 | 2023 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CTR DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R44GM135957 | Ultra-Sensitive Vapor Phase Hydrogen Peroxide Sensor for Decontaminating Pharmaceutical Manufacturing Facilities | 002 | 3 | NIH | 9/8/2023 | $27,669 |
| | 2023 | 2023 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CTR DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R44GM135957 | Ultra-Sensitive Vapor Phase Hydrogen Peroxide Sensor for Decontaminating Pharmaceutical Manufacturing Facilities | 001 | 3 | NIH | 8/30/2023 | $267,144 |
| | 2023 | 2023 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CTR DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R44EY034409 | Ultra-high speed AO-OCT clinical system to image ganglion cells and microglia | 001 | 2 | NIH | 7/31/2023 | $841,839 |
| | 2023 | 2023 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CTR DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | U01FD007689 | Development and Experimental Verification of Fundamental Models to Enable Implementation of Microwave-Assisted Freeze Drying | 000 | 2 | FDA | 9/5/2023 | $120,000 |
| | 2023 | 2023 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CTR DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R44GM135957 | Ultra-Sensitive Vapor Phase Hydrogen Peroxide Sensor for Decontaminating Pharmaceutical Manufacturing Facilities | 000 | 3 | NIH | 1/24/2023 | $799,247 |
| | 2023 | 2023 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CTR DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R43GM148082 | Smart sensor for guiding safe delivery of anesthetic and pain drugs through epidurals | 000 | 1 | NIH | 8/4/2023 | $35,810 |
| | 2023 | 2023 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CTR DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R44MH116748 | Supplemental support for the development of high spatiotemporal resolution neuronal imager | 000 | 3 | NIH | 2/9/2023 | $870,019 |
| | 2023 | 2023 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CTR DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R44MH116748 | Supplemental support for the development of high spatiotemporal resolution neuronal imager | 001 | 3 | NIH | 9/1/2023 | $398,882 |
| | 2023 | 2023 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CTR DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R44CA273961 | Intelligent Optical Probe for Guiding Core Needle Biopsy Procedures | 000 | 2 | NIH | 5/2/2023 | $890,056 |
| | 2023 | 2023 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CTR DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | U01FD007689 | Development and Experimental Verification of Fundamental Models to Enable Implementation of Microwave-Assisted Freeze Drying | 000 | 2 | FDA | 9/5/2023 | $879,842 |
| | 2023 | 2023 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CTR DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R43EY035198 | Evaluation of photoreceptors health and function in diabetic retinopathy patients using a high-resolution retinal imaging device with controlled light stimulus | 000 | 1 | NIH | 8/29/2023 | $331,131 |
| | 2023 | 2023 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CTR DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R44AT010840 | Optical Redox Probe for Continuous Metabolic Monitoring during Natural Products Bioprocessing | 000 | 3 | NIH | 8/4/2023 | $873,502 |
| | 2023 | 2022 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CTR DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R44EY034409 | Ultra-high speed AO-OCT clinical system to image ganglion cells and microglia | 000 | 1 | NIH | 2/13/2023 | $0 |
| | 2023 | 2022 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CTR DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R44DE029631 | Advanced Intraoperative Imager for Nerve Identification | 000 | 2 | NIH | 10/19/2022 | $0 |
| | 2023 | 2021 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CTR DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R44CA240040 | Multimodal Optical Probe for Skin Cancer Detection and Therapy Guidance | 000 | 3 | NIH | 6/14/2023 | $0 |
| | 2023 | 2021 | PHYSICAL SCIENCES INC. | 20 New England Business Ctr Dr | Andover | MA | 01810-1022 | ESSEX | USA | R44OH011711 | Quantitative Methane Plume Imager for Localization and Flow Rate Estimation in Mines | 01 | 2 | CDC | 10/17/2022 | $0 |
| | 2023 | 2021 | PHYSICAL SCIENCES INC. | 20 New England Business Ctr Dr | Andover | MA | 01810-1022 | ESSEX | USA | R44OH011711 | Quantitative Methane Plume Imager for Localization and Flow Rate Estimation in Mines | 01 | 2 | CDC | 10/17/2022 | $0 |
| | 2023 | 2021 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CTR DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R43EB032676 | Smart Multi-grid Template for Focal Therapy of Prostate Cancer | 000 | 1 | NIH | 1/27/2023 | $0 |
| | 2023 | 2021 | PHYSICAL SCIENCES INC. | 20 NEW ENGLAND BUSINESS CTR DR | ANDOVER | MA | 01810-1022 | ESSEX | USA | R43HL156359 | Electrohydraulic impactor for peripheral arterial occlusion management | 000 | 1 | NIH | 3/9/2023 | $0 |
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