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sEH Inhibitors to Treat Neuropathic Pain

Award Number: R44ES025598
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/22/2014
PERIOD OF PERFORMANCE END DATE: 02/28/2019

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sEH Inhibitors to Treat Neuropathic Pain - DESCRIPTION (provided by applicant): With this proposal we aim to further the development of novel and safe oral inhibitors of sEH for the treatment of peripheral neuropathy in diabetic patients. Preclinical studies with our candidate EC5026 demonstrated efficacy for diabetic neuropathy. EicOsis has selected EC5026 for its efficacy with good PK/ADME properties and stability to enter further development stages for this indication. EicOsis also tested the compound and a backup in vitro for off target effects against an array of enzymes, determined the potential inhibition of major cytochrome P450 enzymes, and tested for de-risking with a contract research laboratory. EicOsis has used these data as a basis for an application to work with Blueprint Development Teams to create a development plan and initiate studies to test the safety of EC5026 in Phase 1 clinical trials. To further develop the compounds selected from the completed Phase I application we propose here to radiolabel the candidate and backup to carry out detailed metabolism studies and develop the label as a tracer for human Phase I clinical trial. Additionally we propose to use conventional material to test for off-target toxicity in vivo and to explore the breadth of activity of the inhibitors in alternate pain models. The studies are designed to address understanding metabolism and the spectrum of activity which if lacking often prevent drugs from being developed. The results will empower scientists in the pharmaceutical industry with critical data that speaks to the wider spectrum of activity of sEH inhibitors as analgesics of the future.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2020 ( Subtotal = -$7 )
2020	2017	EICOSIS, LLC	25242 COUNTY ROAD 95	DAVIS	CA	95616	YOLO	USA	Environmental Health	000	3	1/16/2020	SUPPLEMENT FOR EXPANSION	-$7
														Subtotal = -$7

Issue Date FY: 2017 ( Subtotal = $706,510 )
2017	2017	EICOSIS, LLC	1407 NUTMEG LN	DAVIS	CA	95618	YOLO	USA	Environmental Health	001	3	5/19/2017	SUPPLEMENT FOR EXPANSION	$1,382
2017	2017	EICOSIS, LLC	1407 NUTMEG LN	DAVIS	CA	95618	YOLO	USA	Environmental Health	000	3	2/28/2017	NON-COMPETING CONTINUATION	$705,128
														Subtotal = $706,510

Issue Date FY: 2016 ( Subtotal = $807,970 )
2016	2016	EICOSIS, LLC	1407 NUTMEG LN	DAVIS	CA	95618	YOLO	USA	Environmental Health	001	2	9/9/2016	SUPPLEMENT FOR EXPANSION	$76,094
2016	2016	EICOSIS, LLC	1407 NUTMEG LN	DAVIS	CA	95618	YOLO	USA	Environmental Health	000	2	2/25/2016	COMPETING CONTINUATION	$731,876
														Subtotal = $807,970

Grand Total All Awards = $1,514,473

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sEH Inhibitors to Treat Neuropathic Pain

Award Number: R44ES025598

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/22/2014

PERIOD OF PERFORMANCE END DATE: 02/28/2019

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