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Stem cell toxicology assays for cardiac differentiation

Award Number: R44ES023521
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/19/2013
PERIOD OF PERFORMANCE END DATE: 08/31/2018

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Stem cell toxicology assays for cardiac differentiation - ¿ DESCRIPTION (provided by applicant): Defects in heart formation during embryonic and fetal development likely contribute to miscarriages, which terminate up to 25% of all pregnancies, and Congential Heart Defects (CHDs), which are among the most common birth defects. Environmental factors may influence miscarriages and up to 80% of all CHDs, but little is known about how such chemicals affect formation of the heart during early embryonic differentiation. The goal of this SBIR project is to develop a Cardiopoiesis Assay (heart formation assay) to enable testing of compounds to determine if they influence the emergence of cardiac myocytes from multipotent mesodermal progenitors, a critical, early decision point, in heart formation. During the previous Phase I portion of the project, a version of the assay was developed using mouse embryonic stem cells, and this assay has proven useful in identifying chemicals, siRNAs, and miRs that modify cardiac differentiation. For Phase II, we propose to develop the assay using human induced pluripotent stem cells (hiPSCs), which will be derived from multiple donors to increase the genetic diversity represented by the assay. The Cardiopoiesis Assay will be useful in predicting whether chemical compounds affect heart formation in the human embryo, which is of critical importance to human health. The assay will be of interest to government agencies in the US (such as the Environmental Protection Agency) and worldwide, concerned with environmental toxicology.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2017	VALA SCIENCES INC.	6370 NANCY RIDGE DR STE 106	SAN DIEGO	CA	92121	SAN DIEGO	USA	Environmental Health	000	3	8/14/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2017	VALA SCIENCES INC.	6370 NANCY RIDGE DR STE 106	SAN DIEGO	CA	92121	SAN DIEGO	USA	Environmental Health	000	3	5/18/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $738,406 )
2017	2017	VALA SCIENCES INC.	6370 NANCY RIDGE DR STE 106	SAN DIEGO	CA	92121	SAN DIEGO	USA	Environmental Health	000	3	2/9/2017	NON-COMPETING CONTINUATION	$738,406
														Subtotal = $738,406

Issue Date FY: 2016 ( Subtotal = $761,593 )
2016	2016	VALA SCIENCES INC	11099 NORTH TORREY PINES ROAD	LA JOLLA	CA	92037	SAN DIEGO	USA	Environmental Health	000	2	2/9/2016	COMPETING CONTINUATION	$761,593
														Subtotal = $761,593

Grand Total All Awards = $1,499,999

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Stem cell toxicology assays for cardiac differentiation

Award Number: R44ES023521

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/19/2013

PERIOD OF PERFORMANCE END DATE: 08/31/2018

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