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Multimodal Endoscopic Probe for Inner Ear Hearing Loss Diagnosis and Therapy Guidance

Award Number: R44DC015414
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract Sensorineural hearing loss (SNHL) is a source of significant morbidity and in isolated cases is irreversible. Most cases of SNHL are associated with damage or loss of cochlear hair cells. The diagnosis of SNHL is based primarily on audiometric testing as the inner ear cannot be “biopsied” without causing profound hearing loss. Contemporary imaging techniques (computed tomography (CT) and magnetic resonance imaging (MRI)) provide a macroscopic glimpse of peripheral and central auditory pathways but cannot resolve detailed anatomy of the inner ear, at the cellular level. The rapidly growing field of hair cell regeneration is poised to transform our ability to improve SNHL using small molecule or gene therapy approaches but is hampered by the inability to directly image hair cell pathology. Physical Sciences Inc. (PSI), in collaboration with the Eaton Peabody Laboratories at the Massachusetts Eye and Ear Infirmary (MEEI) proposes to develop a multimodal endoscopic imaging system that combines optical coherence tomography (OCT) and auto-fluorescence imaging (AFI) to simultaneously acquire anatomical and biochemical changes of the cochlea, which can be used to diagnose SNHL. During a Phase I program, PSI has developed a bench-top OCT/AFI instrument and has demonstrated the feasibility of this approach to reliably visualize intracochlear anatomy and biochemical functionality in a mouse animal model of SNHL. In a Phase II program we propose to develop an endoscopic OCT/AFI instrument with improved performance, suitable for in vivo use in a large animal model of SNHL. If successful, this technology will be a major step forward in our ability to diagnose SNHL and guide future targeted therapies for inner ear regeneration. Furthermore, this technology will be invaluable in surgical planning during hearing preservation approaches for cochlear implantation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$137 )
2023	2020	PHYSICAL SCIENCES INC.	20 NEW ENGLAND BUSINESS CENTER DR	ANDOVER	MA	01810	ESSEX	USA	Research Related to Deafness and Communication Disorders	000	3	11/10/2022	NON-COMPETING CONTINUATION	-$137
														Subtotal = -$137

Issue Date FY: 2020 ( Subtotal = $555,444 )
2020	2020	PHYSICAL SCIENCES INC.	20 NEW ENGLAND BUSINESS CTR DR	ANDOVER	MA	01810	ESSEX	USA	Research Related to Deafness and Communication Disorders	000	3	3/27/2020	NON-COMPETING CONTINUATION	$555,444
														Subtotal = $555,444

Issue Date FY: 2019 ( Subtotal = $505,632 )
2019	2019	PHYSICAL SCIENCES INC.	20 NEW ENGLAND BUSINESS CTR DR	ANDOVER	MA	01810	ESSEX	USA	Research Related to Deafness and Communication Disorders	001	2	5/7/2019	COMPETING CONTINUATION	-$36,824
2019	2019	PHYSICAL SCIENCES INC.	20 NEW ENGLAND BUSINESS CTR DR	ANDOVER	MA	01810	ESSEX	USA	Research Related to Deafness and Communication Disorders	000	2	5/6/2019	COMPETING CONTINUATION	$542,456
														Subtotal = $505,632

Grand Total All Awards = $1,060,940

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Multimodal Endoscopic Probe for Inner Ear Hearing Loss Diagnosis and Therapy Guidance

Award Number: R44DC015414

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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