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Intelligent Optical Probe for Guiding Core Needle Biopsy Procedures

Award Number: R44CA273961
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/23/2022
PERIOD OF PERFORMANCE END DATE: 04/30/2025

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Intelligent Optical Probe for Guiding Core Needle Biopsy Procedures - Project Summary/Abstract Physical Sciences, Inc. (PSI), in collaboration with MD Anderson Cancer Center (MDACC) proposes to develop and clinically evaluate a novel probe for guiding core needle biopsies. This probe will reveal tissue morphology at the tip of the biopsy needle in real-time and thus aid the interventional radiologist to properly select the biopsy area within the tumor. This is needed because tumors can be very heterogeneous, containing necrotic cells or scar tissue, which do not have any diagnostic value. This biopsy probe, called OptoGuide , is based on the use of a novel encoder-based optical coherence tomography (OCT) approach, which enables in situ tissue imaging with a very simple probe and affordable OCT instrument. We have successfully demonstrated this technology in an animal model of cancer during a previously completed SBIR contract program (HHSN261201600030C). However, further efforts and additional resources are needed to translate this technology to routine clinical use. Thus, the primary goal of this Phase II program is to close the gap between the research and the commercialization phases, enabling technology transition towards clinical use. Specifically, PSI will develop a clinically viable instrument, perform its evaluation on human patients at MDACC, and start generating clinical data needed for regulatory approval and marketing purposes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$22,524 )
2026	2023	PHYSICAL SCIENCES INC.	20 NEW ENGLAND BUSINESS CENTER DR	ANDOVER	MA	01810	ESSEX	USA	Cancer Detection and Diagnosis Research	000	2	12/1/2025	NON-COMPETING CONTINUATION	-$22,524
														Subtotal = -$22,524

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	PHYSICAL SCIENCES INC.	20 NEW ENGLAND BUSINESS CENTER DR	ANDOVER	MA	01810	ESSEX	USA	Cancer Detection and Diagnosis Research	000	2	12/11/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $890,056 )
2023	2023	PHYSICAL SCIENCES INC.	20 NEW ENGLAND BUSINESS CTR DR	ANDOVER	MA	01810	ESSEX	USA	Cancer Detection and Diagnosis Research	000	2	5/2/2023	NON-COMPETING CONTINUATION	$890,056
														Subtotal = $890,056

Issue Date FY: 2022 ( Subtotal = $888,733 )
2022	2022	PHYSICAL SCIENCES INC.	20 NEW ENGLAND BUSINESS CTR DR	ANDOVER	MA	01810	ESSEX	USA	Cancer Detection and Diagnosis Research	000	1	5/23/2022	NEW	$888,733
														Subtotal = $888,733

Grand Total All Awards = $1,756,265

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Intelligent Optical Probe for Guiding Core Needle Biopsy Procedures

Award Number: R44CA273961

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/23/2022

PERIOD OF PERFORMANCE END DATE: 04/30/2025

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