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Administrative Supplement for 'Software Platform for Analyzing Alzheimer's and Parkinson's fMRI Connectomes'

Award Number: R44AG054405
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/15/2016
PERIOD OF PERFORMANCE END DATE: 08/31/2018

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Administrative Supplement for 'Software Platform for Analyzing Alzheimer's and Parkinson's fMRI Connectomes' - DESCRIPTION (provided by applicant): It is estimated that the cost in the US for brain disorders per year is $500 billion for treatment and long term care, with another $400 billion in other nonmedical costs. As a consequence, reducing the burden of human brain disorders is a key focus of the NIH BRAIN Initiative, with one strategy being the use of fMRI connectomes to study brain region functioning. Current approaches for analyzing connectomes use 'off-the-shelf' statistical methods not optimized for this type of data. In this Direct to Phase II SBIR we propose to further develop and strengthen our graphical object oriented data analysis software to solve data analysis, experimental design, and hypothesis testing problems in translational neuroscience. Product: This SBIR will produce analytical software for fMRI data in translational research. Users will access the software through a cloud-based Software-as-a-Service (SaaS) contract. The technical innovation of this SBIR statistical software designed specifically and optimized for fMRI brain imaging data is to support moving fMRI technology from basic R&D to translational clinical science. The impact of this technology are tools to improve brain imaging experimental design, improve biostatistical analysis of brain imaging data, and ultimately improve discovery of biomarkers and identify possible drug targets for clinical treatment. Long term goal: Extending our cloud-based Software-as-a-Service (SaaS) data analytics platform offers researchers an easy to use web-based interface for analyzing new and complex biomedical research data. As a platform technology, there are many applications in other areas of biomedical research that can be developed. Therefore, our business strategy is to identify the areas of science that have the greatest potential to make the move from the university research setting into the commercial arena, and that produce novel or complex data with no commercial analytics tools for translational clinical trials yet on the market. The Specific Aims of this SBIR Direct to Phase II project are: Aim 1: Develop statistical algorithms and software. Aim 2: Validate the methods. Aim 3: Apply the methods to real data. Expected outcomes: Validated statistical software proven to be more powerful than existing methods for analyzing fMRI connectome data in translational research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$17,966 )
2023	2017	WILLIAM D SHANNON CONSULTING LLC	1306 CULVERHILL DR	SAINT LOUIS	MO	63119	SAINT LOUIS	USA	Aging Research	001	2	10/1/2022	SUPPLEMENT FOR EXPANSION	-$3,833
2023	2017	WILLIAM D SHANNON CONSULTING LLC	1306 CULVERHILL DR	SAINT LOUIS	MO	63119	SAINT LOUIS	USA	Aging Research	000	2	10/1/2022	SUPPLEMENT FOR EXPANSION	-$14,133
														Subtotal = -$17,966

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2017	WILLIAM D SHANNON CONSULTING LLC	4041 FOREST PARK AVE STE 302	SAINT LOUIS	MO	63108	SAINT LOUIS CITY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	5/13/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $702,144 )
2017	2017	WILLIAM D SHANNON CONSULTING LLC	4041 FOREST PARK AVE STE 302	SAINT LOUIS	MO	63108	SAINT LOUIS CITY	USA	Aging Research	001	2	9/14/2017	SUPPLEMENT FOR EXPANSION	$149,800
2017	2017	WILLIAM D SHANNON CONSULTING LLC	4041 FOREST PARK AVE STE 302	SAINT LOUIS	MO	63108	SAINT LOUIS CITY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	4/29/2017	NON-COMPETING CONTINUATION	$552,344
														Subtotal = $702,144

Issue Date FY: 2016 ( Subtotal = $551,598 )
2016	2016	WILLIAM D SHANNON CONSULTING LLC	11 TURF COURT	SAINT LOUIS	MO	63119	SAINT LOUIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	5/6/2016	NEW	$551,598
														Subtotal = $551,598

Grand Total All Awards = $1,235,776

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Administrative Supplement for 'Software Platform for Analyzing Alzheimer's and Parkinson's fMRI Connectomes'

Award Number: R44AG054405

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/15/2016

PERIOD OF PERFORMANCE END DATE: 08/31/2018

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