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Single cell tri-omics: High coverage simultaneous profiling of DNA, RNA, and proteins in single cells

Award Number: R43NS135703
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2024
PERIOD OF PERFORMANCE END DATE: 01/31/2026

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Single cell tri-omics: High coverage simultaneous profiling of DNA, RNA, and proteins in single cells - ABSTRACT Alzheimer's disease, a devastating neurologic disorder, accounts for 60-80% of all dementias, making the development of new technologies for studying the disease crucial. Fluid Discovery aims to advance single-cell proteomics with a groundbreaking product called Self-Assembled Partitioning Proteomics (SAP-pm), which will quantify thousands of proteins in hundreds of thousands of individual cells and can be multiplexed with single cell DNA and RNA sequencing. Building on cutting-edge work in microfluidics, biophysics, and genomics, SAP- pm offers a unique, rapid, and cost-effective method to overcome limitations in protein coverage and sensitivity found in current technologies. The project comprises two aims: (1) Develop SAP-pm for sensitive, thousand-plex analysis of proteins at the single cell level, and (2) Expand the capability of SAP-pm to analyze brain nuclei and simultaneously capture mRNA, facilitating valuable insights from primary human tissues to improve human health.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $268,142 )
2024	2024	FLUID DISCOVERY, INC.	953 INDIANA ST	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	1/31/2024	NEW	$268,142
														Subtotal = $268,142

Grand Total All Awards = $268,142

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Single cell tri-omics: High coverage simultaneous profiling of DNA, RNA, and proteins in single cells

Award Number: R43NS135703

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2024

PERIOD OF PERFORMANCE END DATE: 01/31/2026

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