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Revolutionizing Utah Array using Nanotechnology to Enhance Efficacy and Longevity

Award Number: R43NS082036
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2013
PERIOD OF PERFORMANCE END DATE: 02/28/2017

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Revolutionizing Utah Array using Nanotechnology to Enhance Efficacy and Longevity - DESCRIPTION (provided by applicant): In order to successfully use microelectrode arrays for stimulation in chronic implantation, the neural electrode must have longevity and efficacy. Efficacy of stimulation primarily means injecting enough charge to the targeted tissue to elicit action potentials. However, in doing so, the electrode itself must not (1) degrade, (2) generate harmful substances and (3) provoke significant immune response. Attaining the stated requirements remains a challenge as studies have shown loss of discriminable single unit action potentials on the order of weeks, months, or in rare studies, years. Suitable electrode material or strategies that permit prolonged excitation of neurons for long period of time without injuring the tissue or damaging the electrodes are yet to be developed and demonstrated. For the efficacy of the stimulating electrodes, large charge injection capacity (CIC) is desired. CIC depends on the electrode-tissue interface and is characteristic of electrode material used. Though, much of the microelectrode research during the past 30 years has been directed toward the evaluation of various types of materials with regard to individual stimulus charge density limits, till date, in the scientific literature, there is no single material which can avoi over-stimulation i.e. neural damage. In this application, we present a novel surface modification technique that addresses the longevity and efficacy of the microelectrodes in chronic experiments. The three distinct features of our proposed objectives are (1) novel surface modification technique that produces electrochemical characteristics which are by far superior to any material/technology reported in the literature till date. With the surface modified electrodes we were able to achieve electrode impedance of 188 at 1 kHz and CIC of 24 mC/cm2. The high CIC would lower the potential required for stimulation thereby reducing the chances of neural injury and dissolution of electrode material and toxic remnants. Even with the presence of glial sheath, it would not be necessary to go outside the water window thereby reducing the chances of tissue "insult" at the site of stimulation. (2) Biocompatible electrode-tissue interface. It has been postulated by researchers that by manipulating the surface structure of the electrode at micro scale one can reduce astrocyte adhesion around the microelectrode, including reducing the proliferation of glial cells, reduced macrophages and preferential neuron sparing at the site of implant. (3) Simple and inexpensive method of obtaining desired electrode characteristics as opposed to any current thin film deposition method. The objective of this research is to develop, validate, examine (in-vitro, in-vivo and histology) and commercialize the proposed surface modification technology for microelectrodes in chronic experiments. The specific aim of our proposed research is to demonstrate (1) manufacturability of the proposed surface modification for use in a microelectrode array; (2) superior electrochemical properties; (3) improved physiological efficacy; and (4) biocompatible electrode-tissue interface i.e. reduced glial proliferation and reduction in neuronal loss at the biotic-abiotic interface. It is envisioned that with the availability of proposed superior electrochemical characteristics in the neural microelectrode arrays there would be a paradigm shift in the neuroscience research and applications. The enabling innovation has clear clinical benefits in such applications as cortical stimulation and recording, deep brain stimulation, cardiac pacing and pain management and therefore has a significant commercial potential.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2017 ( Subtotal = -$4,919 )
2017	2014	BLACKROCK MICROSYSTEMS, LLC	630 S KOMAS DR STE 200	SALT LAKE CITY	UT	84108	SALT LAKE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	9/28/2017	NON-COMPETING CONTINUATION	-$4,919
														Subtotal = -$4,919

Issue Date FY: 2016 ( Subtotal = $0 )
2016	2014	BLACKROCK MICROSYSTEMS LLC	630 KOMAS DRIVE	SALT LAKE CITY	UT	84108	SALT LAKE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	8/17/2016	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2014 ( Subtotal = $350,000 )
2014	2014	BLACKROCK MICROSYSTEMS LLC	630 KOMAS DRIVE	SALT LAKE CITY	UT	84108	SALT LAKE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	8/15/2014	NON-COMPETING CONTINUATION	$350,000
														Subtotal = $350,000

Issue Date FY: 2013 ( Subtotal = $350,000 )
2013	2013	BLACKROCK MICROSYSTEMS LLC	391 CHIPETA WAY	SALT LAKE CITY	UT	84108	SALT LAKE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	8/30/2013	NEW	$350,000
														Subtotal = $350,000

Grand Total All Awards = $695,081

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Revolutionizing Utah Array using Nanotechnology to Enhance Efficacy and Longevity

Award Number: R43NS082036

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2013

PERIOD OF PERFORMANCE END DATE: 02/28/2017

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