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PORTABLE BRIAN INJURY BIOMARKER DETECTION SYSTEM WITH INTEGRATED MICRODIALYSIS PR

Award Number: R43NS076167
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/15/2011
PERIOD OF PERFORMANCE END DATE: 06/30/2012

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PORTABLE BRIAN INJURY BIOMARKER DETECTION SYSTEM WITH INTEGRATED MICRODIALYSIS PR - DESCRIPTION (provided by applicant): Portable brain injury biomarker detection system with integrated microdialysis probe Project summary/Abstract: This SBIR application aims to integrate microdialysis with an effective, miniature pumping system and a detection system for analyzing different biomarkers in real-time and without user intervention. An integrated portable device consisting of SFC Fluidics' proprietary ePump(R), snap-on magnetic latches for rapid fluidic connection, a reagent reservoir and a microfluidic detection system will be developed. This system will facilitate real time continuous monitoring of pathological biomarkers, which in turn helps in better patient management over the course of healing/therapy. The focus of this SBIR is on monitoring Traumatic Brain Injury (TBI) sequelae with a microdialysis based system using a set of low molar mass biomarkers and a leading large molecule (protein) biomarker. In Phase I, commercially-available ELISA kits will be incorporated into SFC Fluidics integrated microdialysis and fluid handling system. The Phase II focus will be on development of a single prototype system that can quantify multiple TBI biomarkers. Phase I Research Plan Specific Aim: Design and engineer brain injury biomarker detection system with integrated microdialysis probe Task 1: Design and fabricate ePump driven integrated flow system Task 2: Detection of small molecule brain injury biomarkers Task 3: Detection of large molecule brain injury biomarker PUBLIC HEALTH RELEVANCE: An estimated 1.7 million Traumatic Brain injury (TBI) cases are reported every year in United States with 80.7 percent of them resulting in emergency department visits. There is an urgent need for development of a portable, microdialysis system with in-built analyzer which will help in rapid and continuous diagnosis of the state of health of a patient with TBI. Early and timely diagnosis of the pathological condition will help a doctor to take remedial actions and improve the quality of care of the patient while greatly mitigating long-term complications.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2012 ( Subtotal = $0 )
2012	2011	SFC FLUIDICS LLC	535 WEST RESEARCH CENTER BLVD	FAYETTEVILLE	AR	72701	WASHINGTON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	1/19/2012	NEW	$0
														Subtotal = $0

Issue Date FY: 2011 ( Subtotal = $165,780 )
2011	2011	SFC FLUIDICS LLC	535 WEST RESEARCH CENTER BLVD	FAYETTEVILLE	AR	72701	WASHINGTON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	7/5/2011	NEW	$165,780
														Subtotal = $165,780

Grand Total All Awards = $165,780

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PORTABLE BRIAN INJURY BIOMARKER DETECTION SYSTEM WITH INTEGRATED MICRODIALYSIS PR

Award Number: R43NS076167

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/15/2011

PERIOD OF PERFORMANCE END DATE: 06/30/2012

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