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MINIATURE EEG TELEMETRY DEVICE FOR TRANSLATIONAL EPILEPSY RESEARCH

Award Number: R43NS064661
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/22/2009
PERIOD OF PERFORMANCE END DATE: 08/14/2011

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MINIATURE EEG TELEMETRY DEVICE FOR TRANSLATIONAL EPILEPSY RESEARCH - DESCRIPTION (provided by applicant): Long-term continuous recording of electrical events from animal models of neurological disease is a critical component of translational research aimed at developing new therapies for debilitating disorders, such as epilepsy. Recordings of the electroencephalogram (EEG) can be obtained for weeks or months at a time from adult rats with either tethered (i.e., "wired") or telemetric (i.e., "wireless") recording systems; however, both of these systems have problems. The proposed studies will further develop and validate a miniature telemetry system (i.e., the EpiTel device) that will be optimized to record continuous (i.e., virtually uninterrupted) electrographic activity from rodent models of neurological disorders, such as intractable epilepsy. The fundamental principle of the EpiTel device is that a small self-contained telemetry unit with easily replaceable and inexpensive batteries is secured to the rodent's head. If this unit is damaged, it can be readily replaced. A provisional patent for the EpiTel device has been submitted. The proposed experiments will use animal models of acquired epilepsy, and will aim to obtain stable long-term continuous recordings from adult rats and mice with convulsive seizures. The long-term goal is for researchers to be able to use the EpiTel device in translational research to develop new therapies for different types of animal models of acquired epilepsy. We have preliminary "proof-of-principle" data, but aim to test the newly-developed EpiTel device in rat and mouse models of epilepsy. The goal in Phase I is to show that it is feasible to obtain long-term continuous recordings (i.e., for many months at a time). Ultimately, the EpiTel device could also be adapted to immature rats in order to allow studies of pediatric epilepsy. These experiments will allow better validation of animal models of epilepsy and other neurological disorders. The ability to obtain long-term continuous recordings should facilitate the development of new therapies to suppress epileptic seizures and potentially to block the development of chronic epilepsy after brain injury. PUBLIC HEALTH RELEVANCE: This grant proposal aims to develop and validate a new miniature telemetry system for rats and mice that should facilitate translational research on animal models of epilepsy.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2011 ( Subtotal = $0 )
2011	2010	EPITEL INC	615 ARAPEEN DRIVE	SALT LAKE CITY	UT	84108	SALT LAKE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	8/3/2011	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2010 ( Subtotal = $349,978 )
2010	2010	EPITEL INC	615 ARAPEEN DRIVE	SALT LAKE CITY	UT	84108	SALT LAKE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	6/25/2010	NON-COMPETING CONTINUATION	$349,978
														Subtotal = $349,978

Issue Date FY: 2009 ( Subtotal = $349,978 )
2009	2009	EPITEL INC	615 ARAPEEN DRIVE	SALT LAKE CITY	UT	84108	SALT LAKE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	9/21/2009	NEW	$349,978
														Subtotal = $349,978

Grand Total All Awards = $699,956

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MINIATURE EEG TELEMETRY DEVICE FOR TRANSLATIONAL EPILEPSY RESEARCH

Award Number: R43NS064661

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/22/2009

PERIOD OF PERFORMANCE END DATE: 08/14/2011

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