Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

NOVEL NON-INVASIVE DEVICE FOR TREATMENT OF ELEVATED INTRACRANIAL PRESSURES

Award Number: R43NS054372
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: HEALTH SERVICES
PERIOD OF PERFORMANCE START DATE: 02/24/2006
PERIOD OF PERFORMANCE END DATE: 01/31/2007

Group Awards By:

View Award Description

NOVEL NON-INVASIVE DEVICE FOR TREATMENT OF ELEVATED INTRACRANIAL PRESSURES - DESCRIPTION (provided by applicant): Despite advances in the treatment of patients with shock and head injuries, the combination of traumatic brain injury and hemorrhagic shock is the leading cause of death and disability in children and adults in their most productive years. An estimated 1.6 million head injuries occur every year in the United States. The economic consequence of these grave injuries in terms of both lost productivity and the cost of medical care is estimated at over 100 billion dollars annually in the United States alone. While the last two decades of research has resulted in a greater understanding of the physiologic events leading to secondary neuronal injury following polytrauma, therapeutic advances are desperately needed. The goal of this Phase 1 SBIR application is to develop and evaluate a novel device, the intrathoracic pressure regulator (ITPR), intended to decrease the detrimental effects of secondary brain injury following traumatic head injury and shock. This SBIR application is based upon the discovery by the applicants that decreasing intrathoracic pressures with the ITPR lowers intracranial pressures while concurrently increasing cardiac output and blood pressure. The new device is inserted into a standard respiratory circuit between the patient and a means to ventilate the patient. It functions by decreasing a patient's intrathoracic pressure. The decrease in intrathoracic pressure creates a vacuum within the thorax relative to the rest of the body, thereby enhancing blood return to the heart while simultaneously decreasing intracranial pressures. This phase 1 investigation proposes to a) establish proof of concept that a novel intrathoracic pressure regulator valve is a useful and effective resuscitation technology in animals with elevated intracranial pressures and hemorrhagic shock, and b) add a custom variable rate vacuum regulator and prototype a display monitor for the intrathoracic pressure regulator (ITPR) system. If successful, Phase 2 studies will address the potential clinical efficacy of the ITPR in patients with polytrauma including traumatic brain injury. Traumatic brain injury affects hundreds of thousands of Americans each year, accounting for as many as 60,000 deaths and an estimated 70,000 to 90,000 patients with permanent neurologic disabilities. Use of the ITPR is expected to significantly improve patient outcomes, based upon the increase in blood flow to the heart and brain and the lowering of intracranial pressures observed in animal studies. If a significant clinical benefit is demonstrated, the ITPR could become a standard piece of equipment and treatment for patients with hemorrhagic shock and traumatic brain injury.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2006 ( Subtotal = $153,176 )
2006	2006	ADVANCED CIRCULATORY SYSTEMS INC	7615 GOLDEN TRIANGLE DRIVE	EDEN PRAIRIE	MN	55344	HENNEPIN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	2/24/2006	NEW	$153,176
														Subtotal = $153,176

Grand Total All Awards = $153,176

Top

All Categories

About

Search

Reports

Data Submission

Award Information

NOVEL NON-INVASIVE DEVICE FOR TREATMENT OF ELEVATED INTRACRANIAL PRESSURES

Award Number: R43NS054372

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: HEALTH SERVICES

PERIOD OF PERFORMANCE START DATE: 02/24/2006

PERIOD OF PERFORMANCE END DATE: 01/31/2007

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer