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BIO-ENHANCED NEURAL ELECTRODES BASED ON POROUS SILICON

Award Number: R43NS046957
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2004
PERIOD OF PERFORMANCE END DATE: 05/31/2006

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BIO-ENHANCED NEURAL ELECTRODES BASED ON POROUS SILICON - DESCRIPTION (provided by applicant): The overall objective of this program is to develop nanostructured porous silicon as neural electrode materials with enhanced biocompatibility, in particular for novel hybrid silicon/ceramic multi-site neural recording electrode arrays. We have previously shown that the pure ceramic-based multi-site neural electrode arrays can consistently record multiple single neuron activity chronically for up to six weeks. These results are similar to microwire electrodes and better than other thin film electrodes. However, in order for any electrode system to act as neural interface components of neural prosthetic devices, the electrode will be required to record consistently for many years. Preliminary studies have shown that by introducing widely varying porosity into silicon, its behavior can be tuned from that of a relatively bio-inert material to one that is bioactive, and even resorbable. In this proposal, we plan to investigate two types of semi-flexible nanostructured hybrid silicon/ceramic neural electrodes. In one type, the electrode material will be based solely on nanostructured porous silicon formed electrochemically on a thin Si substrate. In the second type of electrode, an additional ultra-thin layer of ceramic material will be formed conformally onto the nanostructured porous silicon using a special deposition process. The latter structure will allow us to directly compare the performance of electrodes with essentially nanostmctured ceramic surface to conventional ceramic-based devices. In Phase I, the efficacy of nanostructured porous silicon neural electrodes will be evaluated in vivo using rat brain model. The neural tissue will be evaluated using histology methods to look for neural damage near the site of implantation and study the growth of neurons into the porous silicon electrodes. To promote neural growth at the electrode/tissue interface and for better contact of the recording sites on the array with neurons, we will test the ability of the porous silicon to deliver neurotrophic molecules. In Phase II, upon optimizing the parameters for nanostructured porous silicon electrodes, Spire and its collaborators will design, fabricate and test in vivo performance of a two dimensional array of porous silicon-based neural electrodes for chronic, long-term (greater than 6 months) multi-site recording.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2005 ( Subtotal = $209,671 )
2005	2005	SPIRE CORPORATION	PATRIOTS PARK	BEDFORD	MA	01730	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	6/14/2005	NON-COMPETING CONTINUATION	$209,671
														Subtotal = $209,671

Issue Date FY: 2004 ( Subtotal = $190,211 )
2004	2004	SPIRE CORPORATION	PATRIOTS PARK	BEDFORD	MA	01730	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	8/12/2004	NEW	$190,211
														Subtotal = $190,211

Grand Total All Awards = $399,882

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BIO-ENHANCED NEURAL ELECTRODES BASED ON POROUS SILICON

Award Number: R43NS046957

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2004

PERIOD OF PERFORMANCE END DATE: 05/31/2006

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