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Microfluidic Cartridge for Point-of-Care Hematology Analysis

Award Number: R43HL167435
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/15/2023
PERIOD OF PERFORMANCE END DATE: 01/16/2024

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Microfluidic Cartridge for Point-of-Care Hematology Analysis - Project Summary/Abstract Evaluation for neutropenia and/or thrombocytopenia requires a 5-part white blood cell (WBC) differential with platelet count. Currently, instruments capable of these measurements must be operated in a CLIA-certified laboratory and rely on complex workflows involving multiple reagents, extensive calibration and maintenance, and operation by highly trained personnel. Turnaround times of hours or days delay administration of critical treatments, such as chemotherapy, anti-psychotic medications, and blood transfusions. Cellia Science will address the need for more rapid blood cell differential tests and develop a device to diagnose neutropenia and thrombocytopenia suitable for point-of-care or low-resource settings. This device will implement label-free deep UV imaging combined with microfluidic “blood smear” preparation and cell classification algorithms to perform blood cell differentials. Cellia’s deep UV images are pseudo-colorized and appear similar to Giemsa-stained images, the current gold standard for manual differentials. However, because we are directly detecting the nucleic acids in the cells, our images are inherently quantitative nucleic acid mass maps with subcellular detail and femtogram sensitivity. In Phase I of this project, we will develop a microfluidic sample cartridge prototype, verify its ability to form the desired cell monolayers, and evaluate the accuracy and precision of counts performed using the cartridge with our imaging device prototype. Blood samples will span the clinically relevant range of hematocrit levels to verify device functionality at varying blood viscosities. Accuracy and precision of the device will be evaluated with samples from healthy patients as well as from patients with neutropenia and thrombocytopenia to demonstrate acceptable performance for the target patient population. Successful development of the microfluidic sample cartridge will demonstrate the feasibility of a scalable, robust sample cartridge for point-of-care hematology analysis. Combined with our existing prototype imaging device and analysis algorithms, this will demonstrate the feasibility of the proposed hematology analyzer.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	CELLIA SCIENCE, INC.	535 W RESEARCH CENTER BLVD STE 135	FAYETTEVILLE	AR	72701	WASHINGTON	USA	Blood Diseases and Resources Research	000	1	2/12/2024	NEW	$0
2024	2023	CELLIA SCIENCE, INC.	535 W RESEARCH CENTER BLVD STE 135	FAYETTEVILLE	AR	72701	WASHINGTON	USA	Blood Diseases and Resources Research	001	1	6/10/2024	NEW	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $275,985 )
2023	2023	CELLIA SCIENCE, INC.	535 W RESEARCH CENTER BLVD STE 135	FAYETTEVILLE	AR	72701	WASHINGTON	USA	Blood Diseases and Resources Research	000	1	2/13/2023	NEW	$275,985
2023	2023	CELLIA SCIENCE, INC.	535 W RESEARCH CENTER BLVD STE 135	FAYETTEVILLE	AR	72701	WASHINGTON	USA	Blood Diseases and Resources Research	001	1	6/21/2023	NEW	$0
														Subtotal = $275,985

Grand Total All Awards = $275,985

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Microfluidic Cartridge for Point-of-Care Hematology Analysis

Award Number: R43HL167435

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/15/2023

PERIOD OF PERFORMANCE END DATE: 01/16/2024

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