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Microfluidic platform for gene delivery into the T-cells

Award Number: R43HL152887
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2020
PERIOD OF PERFORMANCE END DATE: 04/30/2021

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Microfluidic platform for gene delivery into the T-cells - Project Summary Ex vivo genetic m odif ication of blood cells has proven transf orm ational in the treatm ent of hem atologic disorders, most notably the hematologic malignancies using CAR-T or TCR-T cells. Despite considerable investment and some clinical success, gene-modified T cell therapy manufacturing remains costly and inefficient. New delivery technologies are needed to serve this growing market and facilitate access to T cell therapies. The mission of CellFE is to simplify manufacturing of life-saving ex vivo gene therapies using our unique, rapid and efficient capability to deliver gene modifying cargo to patient’s cells. The goal of this project is to test, optimize and scale up a proprietary technology that relies on microfluidic transfection by mechanical manipulation (“mechanotransfection”) to engineer T cells to express transgenes, and simultaneously knock out immune receptors such as T cell receptor (TCR). While the focus of this project is strictly on gene modification of T cells, our platform technology has the potential to impact all ex vivo gene therapy applications, including other blood cells amenable to CAR technology.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	CELLFE INC	980 ATLANTIC AVE	ALAMEDA	CA	94501	ALAMEDA	USA	Blood Diseases and Resources Research	000	1	12/30/2021	NEW	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $284,735 )
2020	2020	CELLFE INC.	2828 PEACHTREE RD NW APT 1201	ATLANTA	GA	30305	FULTON	USA	Blood Diseases and Resources Research	000	1	4/14/2020	NEW	$284,735
														Subtotal = $284,735

Grand Total All Awards = $284,735

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Microfluidic platform for gene delivery into the T-cells

Award Number: R43HL152887

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2020

PERIOD OF PERFORMANCE END DATE: 04/30/2021

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