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L-MOD Therapy: Leukocyte Immunomodulation during Cardiopulmonary Bypass

Award Number: R43HL127830
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2015
PERIOD OF PERFORMANCE END DATE: 06/30/2016

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L-MOD Therapy: Leukocyte Immunomodulation during Cardiopulmonary Bypass - ¿ DESCRIPTION (provided by applicant): The Problem: Cardiovascular disease is the leading cause of death in the Western world. In the US, nearly 500,000 coronary artery bypass surgeries are performed annually with an estimated 89% of these using the technique of cardiopulmonary bypass (CPB). CPB patients experience complications, many of which are considered to be due to the activation of leukocytes (LE) which can result in systemic inflammatory response syndrome (SIRS). The Product: The Leukocyte Modulator (L-MOD) is based on biomimetic membrane device (BMD) platform technology that has been shown to alter the state of systemic LE. When the BMD is placed in a citrated extracorporeal blood circuit, LE are transiently sequestered in the low ionized calcium environment within the BMD and released in an altered state back to the circulation. The L- MOD will be developed specifically to modulate the LE activation associated with CPB, thereby mitigating the associated inflammatory response. Innovation: Previous approaches to block SIRS associated with cardiac surgery including: use of pharmacologic agents, operative techniques, improved biocompatibility and LE depleting filters; have failed to meet clinical endpoints. The L-MOD is the application of BMD technology to CPB associated SIRS and represents an innovative therapy option. The goal of this proposal is to demonstrate efficacy of the L-MOD in ameliorating the inflammatory response and the leukocyte mediated tissue damage that is associated with use of CPB during cardiac procedures. Long Term Goal: This proposal details the initial steps to assess the L-MOD as an effective adjunct therapeutic device to be used in conjunction with current CPB clinical protocol. Phase I Hypothesis: L-MOD therapy will effectively reduce LE activation, minimizing SIRS and accompanying tissue damage resulting from CPB. Specific Aim 1: Confirm a study protocol that results in a robust CPB associated SIRS using a pig model of cardiac surgery with CPB. Specific Aim 2: Compare the SIRS and LE-induced tissue damage resulting from cardiac surgery and CPB with and without including L-MOD therapy using the developed model. Phase II Objective: Phase II will include survival studies in which the ability of LMOD to protect agains organ damage will be evaluated in recovered animals at 24h, with an emphasis on evaluating the safety and efficacy of L-MOD therapy for limiting activated innate immune system-mediated tissue damage occurring in response to on-pump CPB in patients undergoing cardiac surgery. Commercial Opportunity: The LMOD is inexpensive and easy to distribute. Value will be realized in reduced health care cost from CPB complications.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2015	INNOVATIVE BIOTHERAPIES, INC.	650 AVIS DR # 300	ANN ARBOR	MI	48108	WASHTENAW	USA	Blood Diseases and Resources Research	000	1	11/22/2016	NEW	$0
														Subtotal = $0

Issue Date FY: 2015 ( Subtotal = $588,700 )
2015	2015	INNOVATIVE BIOTHERAPIES INC	401 WEST MORGAN ROAD	ANN ARBOR	MI	48108	WASHTENAW	USA	Blood Diseases and Resources Research	000	1	3/4/2015	NEW	$588,700
														Subtotal = $588,700

Grand Total All Awards = $588,700

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L-MOD Therapy: Leukocyte Immunomodulation during Cardiopulmonary Bypass

Award Number: R43HL127830

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2015

PERIOD OF PERFORMANCE END DATE: 06/30/2016

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