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Harmony AI: State of the Art Natural Language Processing for Genetic Engineering

Award Number: R43GM150352
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/22/2023
PERIOD OF PERFORMANCE END DATE: 08/31/2025

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Harmony AI: State of the Art Natural Language Processing for Genetic Engineering - Project Summary/Abstract: Computational techniques for gene engineering, such as codon optimization, use synonymous codon changes to increase protein production. Applications for these computational gene optimizations include recombinant protein drugs, nucleic acid therapies, and mRNA vaccines. Although codon optimization increases protein production in certain systems, synonymous changes to a gene sequence can cause unexpected detrimental results to the protein. Further, researchers have been critical of codon optimization for human therapeutics as the optimization process can affect protein conformation and function, and reduce efficacy. Therefore, codon optimization may not provide an optimal strategy for increasing protein production or designing safe and effective therapeutics. CFDRC has utilized state-of-the-art natural language processing techniques to learn how synonymous codons are used by a target organism and apply this learning to gene engineering. We demonstrated our model could predict the E. Coli synonymous codon usage with 73% accuracy, significantly above prior reports. We believe that using this AI-based approach to gene engineering will provide an optimal strategy for increasing protein production and may increase the efficacy of therapeutics.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $8,053 )
2024	2023	CFD RESEARCH CORPORATION	6820 MOQUIN DR NW STE 300	HUNTSVILLE	AL	35806	MADISON	USA	Biomedical Research and Research Training	000	1	11/15/2023	NEW	$8,053
														Subtotal = $8,053

Issue Date FY: 2023 ( Subtotal = $335,438 )
2023	2023	CFD RESEARCH CORPORATION	6820 MOQUIN DR NW	HUNTSVILLE	AL	35806	MADISON	USA	Biomedical Research and Research Training	000	1	9/22/2023	NEW	$335,438
														Subtotal = $335,438

Grand Total All Awards = $343,491

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Harmony AI: State of the Art Natural Language Processing for Genetic Engineering

Award Number: R43GM150352

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/22/2023

PERIOD OF PERFORMANCE END DATE: 08/31/2025

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