Wednesday, June 18, 2025 6/18/2025

PredictSEP: A Predictive Diagnostic Assay for Sepsis

Award Number: R43GM146559
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/18/2022
PERIOD OF PERFORMANCE END DATE: 12/31/2025

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PredictSEP: A Predictive Diagnostic Assay for Sepsis - Abstract Sepsis is the leading cause of death in hospitals caused by a dysregulated host immune response to infection characterized by excessive neutrophil infiltration into vital organs, organ failure and death. Although blood tests relying on identification of pathogens are widely utilized to decide on treatment, they are severely limited by their ability to rapidly predict the onset, progression and recovery from sepsis. Hence, the goal of this proposal is to design, develop and demonstrate a rapid predictive assay using the native dysfunctional environment of the neutrophil observed in sepsis. This microfluidics-based assay provides quantitation of the neutrophil behavior for a predictive score reflective of the prognosis of the patient. Phase I will focus on validating our assay within 60 minutes with a sample population comprised of sepsis patients, SIRS patients, and healthy controls. Phase II will focus on building an instrumentation for the complete assay along with large patient study and plans for FDA approval.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	CFD RESEARCH CORPORATION	6820 MOQUIN DR NW	HUNTSVILLE	AL	35806	MADISON	USA	Biomedical Research and Research Training	000	1	7/30/2024	NEW	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	CFD RESEARCH CORPORATION	6820 MOQUIN DR NW	HUNTSVILLE	AL	35806	MADISON	USA	Biomedical Research and Research Training	000	1	9/11/2023	NEW	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $342,689 )
2022	2022	CFD RESEARCH CORPORATION	6820 MOQUIN DR NW	HUNTSVILLE	AL	35806	MADISON	USA	Biomedical Research and Research Training	000	1	7/18/2022	NEW	$342,689
														Subtotal = $342,689

Grand Total All Awards = $342,689

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PredictSEP: A Predictive Diagnostic Assay for Sepsis

Award Number: R43GM146559

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/18/2022

PERIOD OF PERFORMANCE END DATE: 12/31/2025

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