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Multi-omics profiling of individual exosomes for their origin-tracing, biomarker discovery, and biological function characterization

Award Number: R43GM145015
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Multi-omics profiling of individual exosomes for their origin-tracing, biomarker discovery, and biological function characterization - PROJECT SUMMARY / ABSTRACT Exosomes, the small extracellular vesicles (30-200 nm), are highly heterogeneous in biofluids. However, traditional bulk-level analysis approaches fail to represent their individual variations. A technique for multi-omics profiling of exosomes at single-particle resolution is of great interest to the exosome research field, but has yet to be developed. WellSIM proposes to develop and validate a method for multi-omics profiling of individual exosomes based on our exosome isolation system (EXODUS), a droplet-based microfluidic device (EXOSeq), and next-generation sequencing (NGS). Our proposed technique will be the first integrative proteomic and transcriptomic profiling of exosomes at the single-particle level, offering high-resolution multi-dimensional biological insights for exosome study and application.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	WELLSIM BIOMEDICAL TECHNOLOGIES INC	930 CORAL RIDGE CIR	RODEO	CA	94572	CONTRA COSTA	USA	Biomedical Research and Research Training	000	1	9/28/2023	NEW	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $256,474 )
2022	2022	WELLSIM BIOMEDICAL TECHNOLOGIES, INC.	930 CORAL RIDGE CIR	RODEO	CA	94572	CONTRA COSTA	USA	Biomedical Research and Research Training	000	1	2/10/2022	NEW	$249,974
2022	2022	WELLSIM BIOMEDICAL TECHNOLOGIES, INC.	930 CORAL RIDGE CIR	RODEO	CA	94572	CONTRA COSTA	USA	Biomedical Research and Research Training	001	1	3/28/2022	SUPPLEMENT FOR EXPANSION	$6,500
														Subtotal = $256,474

Grand Total All Awards = $256,474

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Multi-omics profiling of individual exosomes for their origin-tracing, biomarker discovery, and biological function characterization

Award Number: R43GM145015

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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