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Automated High-throughput Platform for Tissue Homogenization and RNA Extraction

Award Number: R43GM109502
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2014
PERIOD OF PERFORMANCE END DATE: 08/31/2016

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Automated High-throughput Platform for Tissue Homogenization and RNA Extraction - DESCRIPTION (provided by applicant): The overall market size for nucleic acid sample preparation for research and the four applied markets of food testing, cosmetics, veterinary medicine, and molecular diagnostics total $5.7 billion in 2012 and with a moderate CAGR of 10 % is projected to $9.7 billion in 2016 12-5. Extraction of nucleic acids from tissue has become a crowded field yet sample preparation and isolation of RNA still relies heavily on manual steps. Providing a rapid, automated system for tissue preparation and RNA isolation is an unmet need. We have a unique cell and tissue lysing system, the microHomogenizer (mH), which is a low cost, disposable and rapidly effective homogenizing unit. It consists of a disposable motor and vane that attaches to a pipette tip. This facilitates ready adaptation to any robotic liquid handin system for automation and multiplexing. We are poised to multiplex eight samples at a time for homogenization in a microtiter format, thereby enabling automation of the subsequent RNA extraction protocol for 96 samples at a time. The extraction system of 100¿ mono-dispersed beads packed into small columns facilitates extraction protocols that transcend the need of a centrifuge. This enables rapid automation of the extraction protocols in a microtiter format, up 96 samples at time.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2015	CLAREMONT BIOSOLUTIONS LLC	1182 MONTE VISTA AVE 11	UPLAND	CA	91786	SAN BERNARDINO	USA	Biomedical Research and Research Training	000	2	1/4/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2015 ( Subtotal = $342,143 )
2015	2015	CLAREMONT BIOSOLUTIONS LLC	1616 NORTH LAUREL AVENUE	UPLAND	CA	91784	SAN BERNARDINO	USA	Biomedical Research and Research Training	000	2	8/20/2015	NON-COMPETING CONTINUATION	$342,143
														Subtotal = $342,143

Issue Date FY: 2014 ( Subtotal = $349,366 )
2014	2014	CLAREMONT BIOSOLUTIONS LLC	1616 NORTH LAUREL AVENUE	UPLAND	CA	91784	SAN BERNARDINO	USA	Biomedical Research and Research Training	000	1	8/14/2014	NEW	$349,366
														Subtotal = $349,366

Grand Total All Awards = $691,509

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Automated High-throughput Platform for Tissue Homogenization and RNA Extraction

Award Number: R43GM109502

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2014

PERIOD OF PERFORMANCE END DATE: 08/31/2016

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