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Microdomain Thermal Perturbations for Enhanced Nucleation of Proteins

Award Number: R43GM108158
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/10/2015
PERIOD OF PERFORMANCE END DATE: 07/09/2016

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Microdomain Thermal Perturbations for Enhanced Nucleation of Proteins - ¿ DESCRIPTION (provided by applicant): The ability to crystallize proteins for structural biology remains quite challenging, with realized protein crystallization/structure determination success rates hovering around 3%. DeNovX is developing rationally designed nucleation surfaces and thermal methods that enhance success rates and reproducibility for crystallization of proteins and small molecule pharmaceuticals. DeNovX has two complementary platform technologies for improving crystal nucleation, and the combination of these products with micro domain thermal treatment is an innovative and promising approach for proteins, as the micro domain emphasis overcomes protein solubility and stability issues that may adversely affect bulk thermal methods. The long-term goal of this effort is to develop tools to improve success in crystallizing materials that are broadly relevant to research areas ranging from structural biology to new pharmaceutical development. We propose that nucleation of model proteins can be reproducibly accelerated to give crystalline materials by using micro domain thermal treatment in proximity to specially engineered nucleation surfaces. Phase II development will target more diverse proteins including the GPCR's that are both difficult to crystallize and highly relevant to Public Health. DeNovX's complementary technologies for creating tailored nucleation surfaces coupled with innovative thermal treatments will be the basis of a high value consumables product line.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2015	DENOVX, LLC	651 S. SUTTON RD., STE. 300	STREAMWOOD	IL	60107	COOK	USA	Biomedical Research and Research Training	000	1	11/4/2016	NEW	$0
														Subtotal = $0

Issue Date FY: 2015 ( Subtotal = $223,915 )
2015	2015	DENOVX, LLC	DENOVX, LLC	STREAMWOOD	IL	60107	COOK	USA	Biomedical Research and Research Training	000	1	1/9/2015	NEW	$223,915
														Subtotal = $223,915

Grand Total All Awards = $223,915

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Microdomain Thermal Perturbations for Enhanced Nucleation of Proteins

Award Number: R43GM108158

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/10/2015

PERIOD OF PERFORMANCE END DATE: 07/09/2016

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