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INNOVATIVE TECHNOLOGIES TO EFFECTIVELY TREAT MULTI-DRUG RESISTANT AND/OR BIOFILM-

Award Number: R43GM093398
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2010
PERIOD OF PERFORMANCE END DATE: 03/29/2013

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INNOVATIVE TECHNOLOGIES TO EFFECTIVELY TREAT MULTI-DRUG RESISTANT AND/OR BIOFILM- - DESCRIPTION (provided by applicant): This Phase I project is to evaluate a series of novel drug combinations to prevent and treat wound infections. Wounds have certain characteristics that promote the development of infections: the presence of devitalized tissue, foreign bodies, clots, fluid collections, and contamination of wounds with bacteria from the casualty's skin, the environment and the hospital. Medical reports from the military actions in Iraq and Afghanistan confirmed the emergence of multi-drug resistant bacteria (MDR) such as Acinetobacter baumannii, Klebsiella pneumoniae, methicillin-resistant Staphylococcus aureus, and multi-drug resistant Pseudomonas aeruginosa. Infections caused by these multi-drug resistant organisms appear to result in significant morbidity and mortality. Bacteria within biofilms are inherently insensitive to antiseptics, microbicides, and host immune system. To complicate the problem further, the MDR bacteria can form biofilm at the wound sites or implant surfaces, causing infections that are insensitive to host immune system and antibiotic therapies. An effective antimicrobial strategy to prevent and treat biofilm is desperately needed in both military and civilian care. In this project, we propose a series of novel drug combinations as antibiofilm formulations. Efficacy of the antibiofilm formulations will be assessed in a wound dressing model using nanofibrillar chitosan meshes as a topical delivery carrier. The proposed technology combines characteristics including nanofibrillar barrier, hemostatic activity, antibiofilm efficacy, and controlled release strategy. PUBLIC HEALTH RELEVANCE: It was estimated that nosocomial infections affect about 2.0 M people in the U.S. each year and costs more than $11.0 B to the healthcare providers. Wound care and indwelling catheters, the two most commonly associated areas of infection, experienced a surge of antimicrobial devices in the 1990s. By 2007, the US wound care market has grown to an estimated $10 B. This growth has driven efforts to reduce infection that resulted in the development of antimicrobial dressings.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2012 ( Subtotal = $0 )
2012	2010	INNOVATIVE SURFACE TECHNOLOGIES INC	1000 WESTGATE DRIVE	SAINT PAUL	MN	55114	RAMSEY	USA	Biomedical Research and Research Training	000	1	3/27/2012	NEW	$0
														Subtotal = $0

Issue Date FY: 2010 ( Subtotal = $172,763 )
2010	2010	INNOVATIVE SURFACE TECHNOLOGIES INC	1000 WESTGATE DRIVE	SAINT PAUL	MN	55114	RAMSEY	USA	Biomedical Research and Research Training	000	1	9/20/2010	NEW	$172,763
														Subtotal = $172,763

Grand Total All Awards = $172,763

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INNOVATIVE TECHNOLOGIES TO EFFECTIVELY TREAT MULTI-DRUG RESISTANT AND/OR BIOFILM-

Award Number: R43GM093398

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2010

PERIOD OF PERFORMANCE END DATE: 03/29/2013

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