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BRANCHED COPOLYMER AS PEPTIDE DRUG DELIVERY SYSTEM

Award Number: R43GM076849
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: HEALTH SERVICES
PERIOD OF PERFORMANCE START DATE: 03/01/2006
PERIOD OF PERFORMANCE END DATE: 08/31/2007

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BRANCHED COPOLYMER AS PEPTIDE DRUG DELIVERY SYSTEM - DESCRIPTION (provided by applicant): This SBIR Phase I project will develop a novel branched copolymer as a peptide drug delivery carrier for pharmacological application. The carrier is a highly-structured copolymer that can form micelle-like structures with the peptide drug in aqueous media. The stability of this type of molecular structure will minimize early degradation of the encapsulated peptide drug and decrease harmful side-effects from premature drug release. The polymer/drug micelles will exhibit uniform size and drug loading level, and a predictable, well-controlled drug release rate. The overall objective in the Phase I program is to develop a drug delivery system based on the proposed copolymer for pharmacological applications, especially for delivery of peptide drugs. The specific technical aims are: 1. Synthesis and characterization of the polymer drug carrier. 2. Optimization of the polymer/drug encapsulation process and investigation of the drug release rate. A commercially significant model peptide drug will be used for the encapsulation study. The drug release rate from the polymer/drug formulation will be investigated. 3. Determination of the polymer biocompatibility. The potential cytotoxicity of the synthesized polymer will be investigated using in vitro cytotoxicity assays. Potential markets for protein and peptide drug delivery are highly significant. Many of these drugs have stability problems and undesirable side effects. With this proposed new drug delivery system, more efficient drug delivery with lower dosage is possible. This will reduce untoward side effects and enable efficient drug therapy for disease treatment. New drug delivery systems have had an impact on nearly every branch of medicine. Controlled drug delivery is a $20 billion industry and rising rapidly.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2006 ( Subtotal = $125,902 )
2006	2006	EIC LABORATORIES, INC	111 DOWNEY STREET	NORWOOD	MA	02062	NORFOLK	USA	Biomedical Research and Research Training	000	1	2/27/2006	NEW	$125,902
														Subtotal = $125,902

Grand Total All Awards = $125,902

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BRANCHED COPOLYMER AS PEPTIDE DRUG DELIVERY SYSTEM

Award Number: R43GM076849

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: HEALTH SERVICES

PERIOD OF PERFORMANCE START DATE: 03/01/2006

PERIOD OF PERFORMANCE END DATE: 08/31/2007

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