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Novel Approach for Characterizing Exposure and Response to Engineered Nanomaterials in the Gut

Award Number: R43ES030648
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/17/2019
PERIOD OF PERFORMANCE END DATE: 09/30/2020

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Novel Approach for Characterizing Exposure and Response to Engineered Nanomaterials in the Gut - Consumer safety concerns are mounting as engineered nanoparticles (ENPs) are increasingly being incorporated into consumable products, such as food, drugs, and personal care products. While toxicological effects of inhaled and skin-contacting ENPs have been evaluated, very little is known about the short-term and long-term effects of ingested ENPs. To evaluate the safety and possible toxic effects of ENPs on the gastrointestinal (GI) epithelium, human primary cell-based screening assays are urgently needed. Specifically, using more complex, immunocompetent in vitro systems that mimic the native tissue microenvironment would greatly advance our ability to accurately assess the intestinal toxicity of ingested ENPs. The overall objective of this proposal is to develop an in vitro test methodology that accurately determines the toxicological profile of ENPs following intestinal exposure. To achieve this goal, we will utilize MatTek Corporation’s highly differentiated, organotypic EpiIntestinal tissue model containing epithelial cells, fibroblasts, and immune cells. During Phase 1, a prediction model will be developed to identify ENPs that are likely to cause gastrointestinal (GI) irritation, inflammation or genotoxicity, or perturb homeostasis (barrier function) in the GI tract. Since repeat exposure to ENPs is implicated in nanotoxicity, both acute and chronic exposure conditions will be simulated. Such a human cell-based, in vitro GI toxicity model which recapitulates the human small intestine will have enormous market utility for screening ingestible nanomaterials used in the pharmaceutical and food industries.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	MATTEK CORPORATION	200 HOMER AVE	ASHLAND	MA	01721	MIDDLESEX	USA	Environmental Health	000	1	1/31/2021	NEW	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $225,000 )
2019	2019	MATTEK CORPORATION	200 HOMER AVE	ASHLAND	MA	01721	MIDDLESEX	USA	Environmental Health	000	1	4/17/2019	NEW	$225,000
														Subtotal = $225,000

Grand Total All Awards = $225,000

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Novel Approach for Characterizing Exposure and Response to Engineered Nanomaterials in the Gut

Award Number: R43ES030648

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/17/2019

PERIOD OF PERFORMANCE END DATE: 09/30/2020

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