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Rapid Biomonitoring of Volatile Toxins in Human Samples (BIO-VOTO)

Award Number: R43ES025526
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2015
PERIOD OF PERFORMANCE END DATE: 03/31/2017

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Rapid Biomonitoring of Volatile Toxins in Human Samples (BIO-VOTO) - ¿ DESCRIPTION (provided by applicant): Biomonitoring measures chemicals and their metabolites in a person's biological samples, such as blood or urine. It indicates the amount of exposure to chemicals by humans from breathing, touching and ingestion combined from sources including but not limited to air, soil, water, dust, and food. Through the National Biomonitoring Program (NBP) and The National Health and Nutrition Examination Survey, the CDC has established gold standard methods to measure over 450 chemicals and nutritional markers in blood, serum, urine, breast milk and meconium. However, a portable and versatile system is needed to analyze multiple analytes from similar range of samples at the point of sample collection to significantly increase detection accuracy. Additionally, alternative lower cos method is needed to allow large population (epidemiology) studies in order to verify current standards and, if necessary, formulate new guidelines for exposure. We designed an integrated instrument to detect volatile toxin in human samples for rapid biomonitoring that can measure Volatile Organic Compounds (VOCs) concentration in biological samples with a portable, low cost, deployable device, with the sensitivity and specificity similar to a bench top GC-MS (gold standard) system. In preliminary studies, we have demonstrated the novel concept of the device and its ability to accurately measure volatile organics in human plasma. The project milestone for successful completion is the demonstration of a statistically significant correlation of device readout with standard measures of GC-MS in a double-blind study. To achieve this goal, we will build upon our prototype device, which has shown significant sensitivity in rapidly detecting organic compounds in plasma, by implementing software, and hardware changes that would lead to sensitivities and specificities that would enable the measurement of trace biomonitor of VOCs. Successful completion of this work will allow us to proceed to more rigorous testing of the proposed device for ultimate use in biomonitor of VOCs and other toxins in a variety of human samples.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2017 ( Subtotal = -$6 )
2017	2015	CHROMOLOGIC LLC	1225 S SHAMROCK AVE	MONROVIA	CA	91016	LOS ANGELES	USA	Environmental Health	000	1	8/1/2017	NEW	-$6
														Subtotal = -$6

Issue Date FY: 2015 ( Subtotal = $224,993 )
2015	2015	CHROMOLOGIC LLC	1225 SHAMROCK AVENUE	MONROVIA	CA	91016	LOS ANGELES	USA	Environmental Health	000	1	3/25/2015	NEW	$224,993
														Subtotal = $224,993

Grand Total All Awards = $224,987

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Rapid Biomonitoring of Volatile Toxins in Human Samples (BIO-VOTO)

Award Number: R43ES025526

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2015

PERIOD OF PERFORMANCE END DATE: 03/31/2017

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