Tuesday, April 29, 2025
4/29/2025
HIGH-CONTENT ANALYSIS TOOLS FOR DEVELOPMENTAL TOXICITY SCREENS IN ZEBRAFISH - DESCRIPTION (provided by applicant): The zebrafish has become an important new animal model for drug screening, target identification, and validation of various disease models. Although progress has been made in adapting image based high- content screening systems, there are several challenges for automation. To date, the quantitative evaluation of zebrafish assays is performed semi-manually at best, which constitutes a significant bottleneck in terms of workflow and screening cost. In Phase I research, we will specialize software algorithms that will enable automated quantitative assessment of various toxicity endpoints, thus allowing the screening of a large number of potentially toxic compounds. PUBLIC HEALTH RELEVANCE: Use of zebrafish as an alternative animal model for drug screening can greatly accelerate the drug screening process, decrease costs, and provide more accurate results than cell-based assays.
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