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HIGH-CONTENT ANALYSIS TOOLS FOR DEVELOPMENTAL TOXICITY SCREENS IN ZEBRAFISH

Award Number: R43ES017590
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/14/2009
PERIOD OF PERFORMANCE END DATE: 06/30/2010

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HIGH-CONTENT ANALYSIS TOOLS FOR DEVELOPMENTAL TOXICITY SCREENS IN ZEBRAFISH - DESCRIPTION (provided by applicant): The zebrafish has become an important new animal model for drug screening, target identification, and validation of various disease models. Although progress has been made in adapting image based high- content screening systems, there are several challenges for automation. To date, the quantitative evaluation of zebrafish assays is performed semi-manually at best, which constitutes a significant bottleneck in terms of workflow and screening cost. In Phase I research, we will specialize software algorithms that will enable automated quantitative assessment of various toxicity endpoints, thus allowing the screening of a large number of potentially toxic compounds. PUBLIC HEALTH RELEVANCE: Use of zebrafish as an alternative animal model for drug screening can greatly accelerate the drug screening process, decrease costs, and provide more accurate results than cell-based assays.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2009 ( Subtotal = $203,224 )
2009	2009	PHYLONIX PHARMACEUTICALS, INC	100 INMAN STREET SUITE 300	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Environmental Health	000	1	9/11/2009	NEW	$203,224
														Subtotal = $203,224

Grand Total All Awards = $203,224

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HIGH-CONTENT ANALYSIS TOOLS FOR DEVELOPMENTAL TOXICITY SCREENS IN ZEBRAFISH

Award Number: R43ES017590

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/14/2009

PERIOD OF PERFORMANCE END DATE: 06/30/2010

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