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A RAPID LABEL-FREE SENSOR FOR IMMUNE MARKERS OF ENVIRONMENTAL EXPOSURE

Award Number: R43ES016406
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/24/2007
PERIOD OF PERFORMANCE END DATE: 09/09/2009

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A RAPID LABEL-FREE SENSOR FOR IMMUNE MARKERS OF ENVIRONMENTAL EXPOSURE - DESCRIPTION (provided by applicant) Airborne particulate matter (PM) derived from a variety of natural sources (volcanic activity, forest fires) is omnipresent. However, human activity since the industrial revolution and the advent of the internal combustion engine has substantially increased the concentration of PM, particularly in urban areas. Human derived PM tends to be of smaller size, facilitating entry into the body through the respiratory and digestive tracts, as well as through the skin. It also tends to have adsorbed chemical species with greater toxicity than its natural counterparts. The explosive growth of nanotechnology in research and consumer products (sunscreens, cosmetics, paint) is also creating an array of ultrafine materials with largely unknown health effects. Despite numerous studies implicating PM in various disorders including acute respiratory infections, lung cancer, and chronic respiratory and cardiovascular diseases, the specific biological mechanisms involved are not fully understood. Pathologics seeks to leverage its proprietary Arrayed Imaging Reflectometery (AIR) biosensing platform to build a device capable of capturing the detailed physiological response to PM exposure by profiling key marker proteins in conveniently available biosamples such as a finger pick of blood, urine, mucous, saliva, etc. Currently, such testing takes hours and is often done with individual tests. AIR is capable of sensitive and simultaneous protein detection with a device that is currently the size of a laptop computer. The low complexity of the testing platform will also enable the development of handheld units that would be particularly useful for profiling exposure response in the field. In addition to saving time and offering greater convenience these multiplex sensors will allow far more molecular data to be collected than is currently feasible.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2009 ( Subtotal = $192,036 )
2009	2008	PATHOLOGIC ASSOCIATES INC	150 LUCIUS GORDON DRIVE	WEST HENRIETTA	NY	14586	MONROE	USA	Environmental Health	003	1	11/26/2008	SUPPLEMENT FOR EXPANSION	$15,493
2009	2008	PATHOLOGIC ASSOCIATES INC	150 LUCIUS GORDON DRIVE	WEST HENRIETTA	NY	14586	MONROE	USA	Environmental Health	001	1	10/13/2008	SUPPLEMENT FOR EXPANSION	-$154,739
2009	2008	PATHOLOGIC ASSOCIATES INC	150 LUCIUS GORDON DRIVE	WEST HENRIETTA	NY	14586	MONROE	USA	Environmental Health	002	1	10/17/2008	SUPPLEMENT FOR EXPANSION	$139,246
2009	2008	PATHOLOGIC ASSOCIATES INC	150 LUCIUS GORDON DRIVE	WEST HENRIETTA	NY	14586	MONROE	USA	Environmental Health	004	1	9/9/2009	SUPPLEMENT FOR EXPANSION	$0
2009	2007	PATHOLOGIC ASSOCIATES INC	150 LUCIUS GORDON DRIVE	WEST HENRIETTA	NY	14586	MONROE	USA	Environmental Health	000	1	9/9/2009	NEW	$0
2009	2007	PATHOLOGIC ASSOCIATES INC	150 LUCIUS GORDON DRIVE	WEST HENRIETTA	NY	14586	MONROE	USA	Environmental Health	005	2	9/9/2009	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$192,036
														Subtotal = $192,036

Issue Date FY: 2008 ( Subtotal = $170,232 )
2008	2008	PATHOLOGIC ASSOCIATES INC	150 LUCIUS GORDON DRIVE	WEST HENRIETTA	NY	14586	MONROE	USA	Environmental Health	001	1	8/23/2008	SUPPLEMENT FOR EXPANSION	$170,232
														Subtotal = $170,232

Issue Date FY: 2007 ( Subtotal = $192,036 )
2007	2007	PATHOLOGICS LLC	150 LUCIUS GORDON DRIVE	WEST HENRIETTA	NY	14586	MONROE	USA	Environmental Health	000	1	9/20/2007	NEW	$192,036
														Subtotal = $192,036

Grand Total All Awards = $554,304

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A RAPID LABEL-FREE SENSOR FOR IMMUNE MARKERS OF ENVIRONMENTAL EXPOSURE

Award Number: R43ES016406

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/24/2007

PERIOD OF PERFORMANCE END DATE: 09/09/2009

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