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Development of a Bio-tissue Oxygenation Nanophosphor Enabled Sensing (BONES) system for Quantifying Hypoxia in Bone Marrow

Award Number: R42GM142394
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2021
PERIOD OF PERFORMANCE END DATE: 02/29/2024

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Development of a Bio-tissue Oxygenation Nanophosphor Enabled Sensing (BONES) system for Quantifying Hypoxia in Bone Marrow - Project Summary/Abstract Low oxygen (hypoxic) environments are known to be important for maintaining the small number of adult stem cells in the human body, such as in bone marrow. These conditions are also believed to enable dormant cancer cells to survive and metastasize years or decades after the original tumor has been destroyed and the reason why bone marrow is one of the most common sites of cancer metastasis. Understanding of these conditions can drive the development of 3D cellular scaffolds for growing stem cells ex vivo, thus reducing the burden on requiring bone marrow transplants, and for developing therapeutics that prevent cancer relapse. This project proposes to develop the first quantitative oxygen tomographic imaging system called BONES (Bio-tissue Oxygenation Nanophosphor Enabled Sensing) to address the critical need for high resolution imaging of oxygen concentrations in hypoxic (low oxygen) tissues such as bone marrow. The technique is based on developments in x-ray luminescence computed tomography, an emerging molecular imaging technique capable of achieving cellular level resolution and high sensitivities. The approach uses x-rays to excite oxygen-sensitive nanophosphors that emit near-infrared photons to finally enable 3D oxygen measurements in deep bone marrow. Because the technique requires a multidisciplinary team with x-ray expertise, nanophosphor expertise, near-infrared detection expertise, and algorithms for quantifying the concentrations and minimizing dose, this STTR fast-track proposal involves several institutions with deep expertise in their respective domains. The proposed Phase I 6-month project is a proof-of- principle demonstration of a breadboard system used on nanophosphors in low oxygen solutions and embedded in bone. The proposed Phase II 24-month project is to develop a complete prototype system and experimentally verify its performance.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $796,697 )
2023	2023	SIGRAY, INC.	5750 IMHOFF DR STE I	CONCORD	CA	94520	CONTRA COSTA	USA	Biomedical Research and Research Training	000	3	2/22/2023	NON-COMPETING CONTINUATION	$796,697
														Subtotal = $796,697

Issue Date FY: 2022 ( Subtotal = $866,510 )
2022	2022	SIGRAY, INC.	5750 IMHOFF DR STE I	CONCORD	CA	94520	CONTRA COSTA	USA	Biomedical Research and Research Training	002	2	4/13/2022	EXTENSION WITH OR WITHOUT FUNDS	$63,615
2022	2022	SIGRAY, INC.	5750 IMHOFF DR STE I	CONCORD	CA	94520	CONTRA COSTA	USA	Biomedical Research and Research Training	000	2	2/15/2022	EXTENSION WITH OR WITHOUT FUNDS	$866,510
2022	2021	SIGRAY, INC.	5750 IMHOFF DR STE I	CONCORD	CA	94520	CONTRA COSTA	USA	Biomedical Research and Research Training	001	1	4/13/2022	NEW	-$63,615
														Subtotal = $866,510

Issue Date FY: 2021 ( Subtotal = $252,113 )
2021	2021	SIGRAY, INC.	5750 IMHOFF DR STE I	CONCORD	CA	94520	CONTRA COSTA	USA	Biomedical Research and Research Training	000	1	5/17/2021	NEW	$252,113
														Subtotal = $252,113

Grand Total All Awards = $1,915,320

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Development of a Bio-tissue Oxygenation Nanophosphor Enabled Sensing (BONES) system for Quantifying Hypoxia in Bone Marrow

Award Number: R42GM142394

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2021

PERIOD OF PERFORMANCE END DATE: 02/29/2024

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