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Comprehensive Glycoproteomic Tool Development for Cancer Biomarkers

Award Number: R42GM112750
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/22/2014
PERIOD OF PERFORMANCE END DATE: 02/28/2021

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Comprehensive Glycoproteomic Tool Development for Cancer Biomarkers - Project Summary Glycosylation is one of the most prevalent and important post-translational modifications of proteins, yet it is also one of the most difficult to study. No single method nor analytical platform can give complete information about the glycosylation in a protein sample, and the analytical methods in current use include both ESI and MALDI single and tandem mass spectrometry, at least four types of liquid chromatography, iterative enzyme analysis, glycan-binding experiments with fluorescence read-out, and new methods such as ion mobility spectrometry. There is currently no software platform that can integrate even two of these different data channels. In this project we propose to build a software product called GlycoForm that will be capable of analyzing, visualizing, and integrating glycosylation data over multiple channels. GlycoForm will be able to identify released glycans to the level of detail warranted by the evidence and quantify them using either mass spectrometry or fluorescence signals. The software will include both an interactive user interface for expert inspection, and also customized and automated glycosylation reports for sharing and archiving. The initial release of GlycoForm will handle single and tandem mass spectrometry, chromatographic elution time, and glycan-binding experiments; other data channels will be added later in response to customer demand.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	PROTEIN METRICS INC.	20863 STEVENS CREEK BLVD STE 450	CUPERTINO	CA	95014	SANTA CLARA	USA	Biomedical Research and Research Training	000	5	7/2/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $315,614 )
2019	2019	PROTEIN METRICS INC.	20863 STEVENS CREEK BLVD STE 450	CUPERTINO	CA	95014	SANTA CLARA	USA	Biomedical Research and Research Training	000	5	8/15/2019	NON-COMPETING CONTINUATION	$315,614
														Subtotal = $315,614

Issue Date FY: 2018 ( Subtotal = $315,614 )
2018	2018	PROTEIN METRICS INC.	1622 SAN CARLOS AVE, SUITE C	SAN CARLOS	CA	94070	SAN MATEO	USA	Biomedical Research and Research Training	000	4	8/24/2018	NON-COMPETING CONTINUATION	$315,614
														Subtotal = $315,614

Issue Date FY: 2017 ( Subtotal = $315,614 )
2017	2017	PROTEIN METRICS INC.	1622 SAN CARLOS AVE, SUITE C	SAN CARLOS	CA	94070	SAN MATEO	USA	Biomedical Research and Research Training	000	3	9/8/2017	COMPETING CONTINUATION	$315,614
														Subtotal = $315,614

Grand Total All Awards = $946,842

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Comprehensive Glycoproteomic Tool Development for Cancer Biomarkers

Award Number: R42GM112750

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/22/2014

PERIOD OF PERFORMANCE END DATE: 02/28/2021

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