Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

A user-friendly microfluidic chip for anti-epileptogenic drug screening

Award Number: R41NS108895
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2018
PERIOD OF PERFORMANCE END DATE: 08/31/2020

Group Awards By:

View Award Description

A user-friendly microfluidic chip for anti-epileptogenic drug screening - New pharmacological treatments for epilepsy will be discovered through the development of new screening platforms that are rapid, reliable, and can identify novel disease-modifying therapies, or anti-epileptogenic treatments. Xona Microfluidic, LLC (“Xona”) is in a unique position to provide such screening tools and services for epilepsy research. Xona focuses on the development of microfluidic platforms for neuron cell culture and provides devices that allow compartmentalization and fluidic isolation of axons and/or dendrites, and somata. We have patented technology and have sold devices to hundreds of labs world-wide, including many pharmaceutical laboratories. Epileptogenesis induces an imbalance in inhibitory/excitatory circuits within the brain, leading to hyper-excitability and seizures. A common cause of epilepsy is brain damage due to traumatic brain injury or stroke, often involving pyramidal cells within the hippocampus. Our academic partners at UNC recently demonstrated the reliable induction of hyper-excitability in pyramidal cells using a standard neuron device (SND) configuration microfluidic chamber in response to axotomy (Nagendran et al., Nature Communications, 2017). This hyper-excitability, which involves an imbalance of excitation and inhibition, develops reliably and with a delay, at two days after axotomy. In separate NIH funding, we dramatically improved the manufacturability of our platform leading to fully assembled, more robust devices. Here we will develop a new platform optimized for screening anti-epileptogenic compounds to provide a much needed screening service to researchers as well as current and future pharmaceutical customers. Aim 1 focuses on developing a new injection moldable platform optimized to increase axon damage in a multi-well format. Aim 2 will lead to the development of an immunoassay to rapidly measure inhibitory/excitatory balance within this microfluidic screening platform.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2018	XONA MICROFLUIDICS, INC.	76 TW ALEXANDER DR	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	5/15/2021	NEW	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2018	XONA MICROFLUIDICS, LLC	43300 BUSINESS PARK DR STE 204	TEMECULA	CA	92590	RIVERSIDE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	3/7/2019	NEW	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $225,000 )
2018	2018	XONA MICROFLUIDICS, LLC	27574 COMMERCE CENTER DR STE 137	TEMECULA	CA	92590	RIVERSIDE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	8/16/2018	NEW	$225,000
														Subtotal = $225,000

Grand Total All Awards = $225,000

Top

All Categories

About

Search

Reports

Data Submission

Award Information

A user-friendly microfluidic chip for anti-epileptogenic drug screening

Award Number: R41NS108895

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2018

PERIOD OF PERFORMANCE END DATE: 08/31/2020

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer