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Cuff Electrodes with Soft Wire Electrical Leads

Award Number: R41NS108865
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2018
PERIOD OF PERFORMANCE END DATE: 02/28/2022

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Cuff Electrodes with Soft Wire Electrical Leads - Project Summary/Abstract “Development of a Nerve Cuff Electrode from Soft and Elastomeric Conducting Wires STTR Phase I Application” PI: Brady Clapsaddle, TDA Research, Inc. Bio-electronic interfaces are used in a wide array of applications for recording and providing electrical impulses to treat disease. One common interface device for the PNS is the cuff electrode. Current cuff electrodes have many failure modes, most commonly breakage of the brittle metal microwire leads during implantation or regular movement. Stiff metal wires also irritate soft tissue, leading to inflammatory response and scarring. Researchers and clinicians have realized that increased lifetime and ease of implantation of cuff electrodes would greatly benefit research and electrotherapy, prompting advances in commercial cuff electrodes in recent years. The development of materials that are easier to implant and have better tissue compatibility has been at the forefront of these advances. These new cuffs however, still mainly use metal microwires for contact with the tissue. Conducting polymers and carbonaceous materials offer better mechanical compatibility with tissues than their metal counterparts. TDA has recently developed a soft, elastomeric wire material that is compatible with tissue. Furthermore, TDA's wires are elastic, stretching to >200% of their original size (depending on formulation), and thus TDA's soft wires have the potential to eliminate many failure modes of traditional cuff electrodes by replacing brittle metal microwires. Due to their stretchable, pliable nature, TDA's soft wires can withstand the stress of implantation and result in robust interfaces with hardware. Using these materials, we propose to develop novel cuff electrodes with soft polymeric electrical leads to improve durability, ease of implantation, and tissue compatibility of cuff electrodes for applications in the peripheral nervous system (PNS). Our approach is to fabricate cuff electrodes with flexible conducting wires. Once fabricated, our collaborators at the University of Pittsburgh will demonstrate implantability in the PNS, acute in vivo functionality, and long term performance in a chronic in vivo study.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$20,410 )
2023	2019	TDA RESEARCH, INC.	4680 TABLE MOUNTAIN DR	GOLDEN	CO	80403	JEFFERSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	5/15/2023	NON-COMPETING CONTINUATION	-$20,410
														Subtotal = -$20,410

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	TDA RESEARCH, INC.	12345 W 52ND AVE	WHEAT RIDGE	CO	80033	JEFFERSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	6/24/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2019	TDA RESEARCH, INC.	12345 W 52ND AVE	WHEAT RIDGE	CO	80033	JEFFERSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	1/14/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $245,102 )
2019	2019	TDA RESEARCH, INC.	12345 W 52ND AVE	WHEAT RIDGE	CO	80033	JEFFERSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	8/30/2019	NON-COMPETING CONTINUATION	$245,102
														Subtotal = $245,102

Issue Date FY: 2018 ( Subtotal = $246,541 )
2018	2018	TDA RESEARCH, INC.	12345 W 52ND AVE	WHEAT RIDGE	CO	80033	JEFFERSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	8/17/2018	NEW	$246,541
														Subtotal = $246,541

Grand Total All Awards = $471,233

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Cuff Electrodes with Soft Wire Electrical Leads

Award Number: R41NS108865

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2018

PERIOD OF PERFORMANCE END DATE: 02/28/2022

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