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Integrated Platform for Mass Spectrometric Studies of Protein Structure

Award Number: R41GM121133
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2017
PERIOD OF PERFORMANCE END DATE: 02/28/2019

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Integrated Platform for Mass Spectrometric Studies of Protein Structure - Summary Technology for studying the higher order structure (HOS) of biomolecules encompasses some of the most important tools in all of science, and is a highlighted NIGMS research topic. Mass- spectrometric methods for studying HOS include oxidative footprinting and other methods to covalently label amino acid side-chain functional groups, and also hydrogen/deuterium exchange (HDX) on protein backbone amides. These methods require only small amounts of not-necessarily-pure material, and can study conformation and dynamics of proteins in solution with or without ligands. Mass spectrometric methods are especially well suited to biopharma comparability and epitope mapping studies. Currently, there is no software that can analyze mass spectrometric data from both chemical labeling and HDX experiments, even though the two methods both probe solvent accessibility and, if combined, would give finer resolution and greater confidence. Protein Metrics has already built beta-test software for covalent labeling, including Fast Photochemical Oxidation of Proteins (FPOP). The proposed project will focus on data analysis software for HDX experiments. The outcome will be vendor-neutral software with advanced analytical and reporting capabilities that can handle both HDX and covalent labeling experiments.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2017	PROTEIN METRICS INC.	20863 STEVENS CREEK BLVD STE 450	CUPERTINO	CA	95014	SANTA CLARA	USA	Biomedical Research and Research Training	000	1	6/28/2019	NEW	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $210,175 )
2017	2017	PROTEIN METRICS INC.	1622 SAN CARLOS AVE, SUITE C	SAN CARLOS	CA	94070	SAN MATEO	USA	Biomedical Research and Research Training	000	1	8/29/2017	NEW	$210,175
														Subtotal = $210,175

Grand Total All Awards = $210,175

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Integrated Platform for Mass Spectrometric Studies of Protein Structure

Award Number: R41GM121133

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2017

PERIOD OF PERFORMANCE END DATE: 02/28/2019

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