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Metal ion-functionalized soluble nanopolymers: A new analytical platform for plas

Award Number: R41GM109626
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/25/2014
PERIOD OF PERFORMANCE END DATE: 08/31/2017

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Metal ion-functionalized soluble nanopolymers: A new analytical platform for plas - DESCRIPTION (provided by applicant): Mass spectrometry-based proteomics is an emerging technology that has seen possible applications everywhere. The technique can potentially use one drop of our blood to reveal onset and progress of diseases. Current R&D using plasma/serum proteome sample sets, however, is severely limited by the high complexity and dynamic range of protein concentrations. Vast majority of plasma/serum proteomic strategies lack adequate reproducibility, sensitivity, and robustness for clinical tests. Solutions for these serious technological barriers to develop a reliable detection platform toward clinical implementation are elusive. In this NIH STTR Phase I study, we will develop a novel analytical platform based on functionalized soluble nanopolymers into commercial products for simple, routine serum/plasma biomarker discovery. Through this STTR Phase I project, we will leap from our expertise in pioneering the application of soluble nanopolymers to establish Polymer-based Metal Ion Affinity Capture (PolyMAC) functionalized with different metal ions as a powerful platform for sequential depletion of high-abundant proteins and isolation of low abundant plasma proteins to achieve sensitive, reproducible and quantitative plasma proteomics. In particular, we will validate the platform through analyzing plasma samples including those from Ossabaw swine, a distinctive large animal model for early detection of coronary artery disease (CAD). In order to achieve these goals, the following aims will be completed: Aim #1: Optimization of PolyMAC-Cu for high-abundant plasma protein depletion. Aim #2: Optimization of in-depth plasma proteome analyses using sequential PolyMAC-M isolations. By the completion of STTR Phase I studies, we expect to develop a versatile sample preparation platform with core reagents and kits for plasma proteomics and to facilitate translating proteomics discovery to clinical applications.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2015	TYMORA ANALYTICAL OPERATIONS, LLC	3495 KENT AVE STE E400	WEST LAFAYETTE	IN	47906	TIPPECANOE	USA	Biomedical Research and Research Training	000	2	9/26/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2015 ( Subtotal = $328,449 )
2015	2015	TYMORA ANALYTICAL OPERATIONS LLC	1281 WIN HENTSCHEL BOULEVARD	WEST LAFAYETTE	IN	47906	TIPPECANOE	USA	Biomedical Research and Research Training	000	2	8/7/2015	NON-COMPETING CONTINUATION	$328,449
														Subtotal = $328,449

Issue Date FY: 2014 ( Subtotal = $312,537 )
2014	2014	TYMORA ANALYTICAL OPERATIONS LLC	1281 WIN HENTSCHEL BOULEVARD	WEST LAFAYETTE	IN	47906	TIPPECANOE	USA	Biomedical Research and Research Training	000	1	9/23/2014	NEW	$312,537
														Subtotal = $312,537

Grand Total All Awards = $640,986

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Metal ion-functionalized soluble nanopolymers: A new analytical platform for plas

Award Number: R41GM109626

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/25/2014

PERIOD OF PERFORMANCE END DATE: 08/31/2017

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