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Action and interaction of ionotropic and metabotropic neurotransmission

Award Number: R37NS046579
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2004
PERIOD OF PERFORMANCE END DATE: 11/30/2024

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Action and interaction of ionotropic and metabotropic neurotransmission - Project Abstract The many classes of neurons in the mammalian brain use many different neurotransmitters to communicate. Nevertheless, it has generally been assumed that each neuron uses one principal neurotransmitter. This notion has dominated the analysis of the contributions of synaptic transmission to circuit function and behavior. However, we and others have found that many neurons in the mammalian brain actually release several neurotransmitters at the same time, often targeting each neurotransmitter to a specific and different postsynaptic cell class. We propose that the co-released neurotransmitters act in concert to have consistent and mutually reinforcing effects on their enclosing circuit. Here we propose to study the integration and coordination of peptidergic, GABAergic, and cholinergic signaling and reveal how these diverse signaling molecules act together to dictate the activity and plasticity state of cerebral cortex. The pathways that we have uncovered are potentially powerful means of regulating cortical function and may, in the future, be exploited to restore cognitive function in neurodegenerative disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$22,759 )
2025	2024	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	20	4/1/2025	NON-COMPETING CONTINUATION	-$22,759
														Subtotal = -$22,759

Issue Date FY: 2024 ( Subtotal = $654,536 )
2024	2024	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	20	11/27/2023	NON-COMPETING CONTINUATION	$607,303
2024	2024	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	20	4/10/2024	NON-COMPETING CONTINUATION	$47,233
														Subtotal = $654,536

Issue Date FY: 2023 ( Subtotal = $683,255 )
2023	2023	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	19	1/30/2023	NON-COMPETING CONTINUATION	$68,325
2023	2023	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	19	11/22/2022	NON-COMPETING CONTINUATION	$614,930
2023	2022	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	18	11/19/2022	EXTENSION WITH OR WITHOUT FUNDS	$22,759
2023	2021	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	17	11/19/2022	NON-COMPETING CONTINUATION	-$22,759
														Subtotal = $683,255

Issue Date FY: 2022 ( Subtotal = $685,824 )
2022	2022	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	18	2/1/2022	EXTENSION WITH OR WITHOUT FUNDS	$13,987
2022	2022	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	18	3/29/2022	EXTENSION WITH OR WITHOUT FUNDS	$68,582
2022	2022	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	18	1/21/2022	EXTENSION WITH OR WITHOUT FUNDS	$603,255
														Subtotal = $685,824

Issue Date FY: 2021 ( Subtotal = $682,298 )
2021	2021	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	17	11/23/2020	NON-COMPETING CONTINUATION	$614,068
2021	2021	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	17	1/12/2021	NON-COMPETING CONTINUATION	$68,230
2021	2020	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	16	11/5/2020	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $682,298

Issue Date FY: 2020 ( Subtotal = $635,228 )
2020	2020	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	16	7/23/2020	SUPPLEMENT FOR EXPANSION	$23,535
2020	2020	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	16	11/18/2019	NON-COMPETING CONTINUATION	$550,524
2020	2020	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	16	2/11/2020	NON-COMPETING CONTINUATION	$61,169
														Subtotal = $635,228

Issue Date FY: 2019 ( Subtotal = $611,693 )
2019	2019	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	15	11/21/2018	NON-COMPETING CONTINUATION	$611,693
														Subtotal = $611,693

Issue Date FY: 2018 ( Subtotal = $611,693 )
2018	2018	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	14	11/27/2017	COMPETING CONTINUATION	$611,693
														Subtotal = $611,693

Grand Total All Awards = $4,541,768

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Action and interaction of ionotropic and metabotropic neurotransmission

Award Number: R37NS046579

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2004

PERIOD OF PERFORMANCE END DATE: 11/30/2024

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