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Statistical methods to localize disease heritability and identify biological mechanisms

Award Number: R37MH107649
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2015
PERIOD OF PERFORMANCE END DATE: 05/31/2028

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Statistical methods to localize disease heritability and identify biological mechanisms - Genetic studies of both common and rare genetic variation have been extremely successful in identifying genes and variants associated to schizophrenia, autism and other psychiatric disorders. Nevertheless, for most psychiatric disorders, the vast majority of genetic effects are as yet undetected. Our specific aims are to 1) quantify the heritability explained by rare and functional classes of variation; 2) boost association power via leveraging related traits; and 3) infer biological mechanisms via local fine-mapping and genome- wide causal inference. We will guide our research using >800,000 samples from genome-wide association, exome sequencing and genome sequencing studies of psychiatric disease. The methods we propose to develop will be implemented in software packages that we will make widely available to the community.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $824,028 )
2025	2025	THE BROAD INSTITUTE, INC	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Mental Health Research Grants	000	11	6/12/2025	NON-COMPETING CONTINUATION	$824,028
														Subtotal = $824,028

Issue Date FY: 2024 ( Subtotal = $842,036 )
2024	2024	THE BROAD INSTITUTE, INC	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Mental Health Research Grants	002	10	5/21/2024	NON-COMPETING CONTINUATION	$842,036
2024	2023	THE BROAD INSTITUTE, INC	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Mental Health Research Grants	001	9	5/17/2024	EXTENSION WITH OR WITHOUT FUNDS	$167,492
2024	2022	THE BROAD INSTITUTE, INC	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Mental Health Research Grants	000	8	5/17/2024	NON-COMPETING CONTINUATION	-$167,492
														Subtotal = $842,036

Issue Date FY: 2023 ( Subtotal = $835,357 )
2023	2023	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Mental Health Research Grants	001	9	8/2/2023	EXTENSION WITH OR WITHOUT FUNDS	$835,357
2023	2022	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Mental Health Research Grants	000	8	8/1/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $835,357

Issue Date FY: 2022 ( Subtotal = $846,669 )
2022	2022	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Mental Health Research Grants	000	8	5/26/2022	NON-COMPETING CONTINUATION	$846,669
														Subtotal = $846,669

Issue Date FY: 2021 ( Subtotal = $1,071,653 )
2021	2021	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Mental Health Research Grants	000	7	6/16/2021	NON-COMPETING CONTINUATION	$946,273
2021	2021	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Mental Health Research Grants	001	7	8/5/2021	SUPPLEMENT FOR EXPANSION	$125,380
														Subtotal = $1,071,653

Issue Date FY: 2020 ( Subtotal = $981,694 )
2020	2020	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Mental Health Research Grants	000	6	5/19/2020	NON-COMPETING CONTINUATION	$755,517
2020	2020	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Mental Health Research Grants	001	6	9/25/2020	SUPPLEMENT FOR EXPANSION	$226,177
														Subtotal = $981,694

Issue Date FY: 2019 ( Subtotal = $767,644 )
2019	2019	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Mental Health Research Grants	000	5	9/4/2019	NON-COMPETING CONTINUATION	$767,644
														Subtotal = $767,644

Grand Total All Awards = $6,169,081

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Statistical methods to localize disease heritability and identify biological mechanisms

Award Number: R37MH107649

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2015

PERIOD OF PERFORMANCE END DATE: 05/31/2028

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