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Effort-Based Decision Making and Motivated Behavior in Everyday Life

Award Number: R37MH066031
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2023
PERIOD OF PERFORMANCE END DATE: 01/31/2028

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Effort-Based Decision Making and Motivated Behavior in Everyday Life - Motivational impairments are a key feature of both psychotic and mood disorders. Decreases in motivation impair work and social function transdiagnostically, reduce quality of life, and increase public health demands. Current treatments are not sufficiently effective at reducing impairments in motivation, in part due to the need to better understand the mechanisms that give rise to these symptoms. The work in the prior round of funding provided strong evidence that abnormal effort-cost decision-making (ECDM; Effort valuation/Willingness to work in the RDoC Positive Valence System) may be a key contributor to motivational deficits in psychotic pathology (i.e., individuals with schizophrenia, schizoaffective disorder and bipolar disorder), but not among individuals with mood pathology (i.e., Major Depression). ECDM refers to calculations that individuals perform to estimate the amount of physical or cognitive work required to obtain a reward. Individuals with schizophrenia, schizoaffective, bipolar disorder are less motivated than healthy individuals to exert effort to obtain rewards on experimental tasks of ECDM, with associated deficits in dorsal-fontal parietal control systems, and these deficits are related to symptoms of amotivation and function in everyday life. Individuals with depression did not show such deficits on tasks of either physical or cognitive effort, despite showing clear evidence of anhedonia in everyday life. These data strongly support our hypotheses that the mechanisms that contribute to motivational impairments in psychosis differ from those in depression. Here we expand this work. In Aim 1 we will utilize novel behavioral and imaging paradigms derived from the affective science literature to assess social and non-social motivation (Consultant Sommerville, co-I Braver) to test the hypothesis that individuals with psychosis will show even greater impairment in effort allocation for social than monetary rewards, while individuals with depression will show equal impairments in both. In Aim 2, we will integrate state-of-the art neuroimaging methods (neuromelanin) to indirectly measure dopamine function (consultant Horga) to test the hypothesis that dopamine disruption will be more strongly related to indices of motivational impairments in depression versus psychosis. In Aim 3, we will incorporate innovative mobile technologies to longitudinally assess social and non-social motivated behavior and cognition (Consultant Gershon) in everyday life, testing the hypotheses that the magnitude of motivational impairments in psychosis will covary over time with cognitive impairments among individuals with psychosis, but not among individuals with depression.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $736,081 )
2026	2026	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Mental Health Research Grants	000	18	2/6/2026	NON-COMPETING CONTINUATION	$736,081
														Subtotal = $736,081

Issue Date FY: 2025 ( Subtotal = $749,031 )
2025	2025	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Mental Health Research Grants	000	17	1/24/2025	NON-COMPETING CONTINUATION	$636,677
2025	2025	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Mental Health Research Grants	001	17	9/18/2025	NON-COMPETING CONTINUATION	$112,354
														Subtotal = $749,031

Issue Date FY: 2024 ( Subtotal = $760,823 )
2024	2024	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63110	SAINT LOUIS CITY	USA	Mental Health Research Grants	000	16	1/12/2024	NON-COMPETING CONTINUATION	$684,741
2024	2024	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63110	SAINT LOUIS CITY	USA	Mental Health Research Grants	001	16	5/13/2024	NON-COMPETING CONTINUATION	$76,082
2024	2023	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Mental Health Research Grants	003	15	9/19/2024	EXTENSION WITH OR WITHOUT FUNDS	$9,007
2024	2022	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Mental Health Research Grants	002	14	9/19/2024	NON-COMPETING CONTINUATION	-$9,007
														Subtotal = $760,823

Issue Date FY: 2023 ( Subtotal = $755,898 )
2023	2023	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Mental Health Research Grants	001	15	3/30/2023	EXTENSION WITH OR WITHOUT FUNDS	$755,898
2023	2022	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Mental Health Research Grants	000	14	3/29/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $755,898

Issue Date FY: 2022 ( Subtotal = $655,276 )
2022	2022	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Mental Health Research Grants	000	14	1/31/2022	NON-COMPETING CONTINUATION	$589,749
2022	2022	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Mental Health Research Grants	001	14	6/26/2022	NON-COMPETING CONTINUATION	$65,527
														Subtotal = $655,276

Issue Date FY: 2021 ( Subtotal = $680,736 )
2021	2021	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Mental Health Research Grants	000	13	1/26/2021	NON-COMPETING CONTINUATION	$680,736
														Subtotal = $680,736

Issue Date FY: 2020 ( Subtotal = $697,531 )
2020	2020	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Mental Health Research Grants	000	12	1/10/2020	NON-COMPETING CONTINUATION	$697,531
														Subtotal = $697,531

Issue Date FY: 2019 ( Subtotal = $716,941 )
2019	2019	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Mental Health Research Grants	000	11	1/29/2019	NON-COMPETING CONTINUATION	$716,941
														Subtotal = $716,941

Issue Date FY: 2018 ( Subtotal = $794,679 )
2018	2018	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Mental Health Research Grants	000	10	5/22/2018	COMPETING CONTINUATION	$794,679
														Subtotal = $794,679

Grand Total All Awards = $6,546,996

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Effort-Based Decision Making and Motivated Behavior in Everyday Life

Award Number: R37MH066031

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2023

PERIOD OF PERFORMANCE END DATE: 01/31/2028

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