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Towards Curative Therapies for Hypogonadotropic Diseases

Award Number: R37HD043341
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2003
PERIOD OF PERFORMANCE END DATE: 08/31/2025

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Towards Curative Therapies for Hypogonadotropic Diseases - PROJECT ABSTRACT Kisspeptin, neurokinin B, and dynorphin signaling provide essential guidance and stimulation to GnRH neurons. Though the past decade has seen extraordinary advances in our understanding of this signaling network, this grant employs novel assays and receptor agonist and antagonist administration in vivo to challenge several dogmas in reproductive endocrinology. These complementary approaches, performed in rhesus monkeys, healthy volunteers, and patients with reproductive disease, unite two investigators with experience in genetics, physiology, and pharmacology. This interdisciplinary collaboration is well positioned to attack the complexities of the hypothalamic architecture that regulates GnRH secretion. Thus, by translating fluidly between monkey and man, between juvenile and adult, and between physiology and pathophysiology, this grant aims to generate novel insights into sexual maturation and develop new treatments for patients with reproductive disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	23	11/21/2025	EXTENSION WITH OR WITHOUT FUNDS	$0
2026	2024	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Child Health and Human Development Extramural Research	001	22	2/25/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $892,586 )
2025	2025	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	23	8/17/2025	EXTENSION WITH OR WITHOUT FUNDS	$892,586
														Subtotal = $892,586

Issue Date FY: 2024 ( Subtotal = $785,188 )
2024	2024	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	22	8/29/2024	NON-COMPETING CONTINUATION	$785,188
														Subtotal = $785,188

Issue Date FY: 2023 ( Subtotal = $793,120 )
2023	2023	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	21	8/14/2023	NON-COMPETING CONTINUATION	$793,120
														Subtotal = $793,120

Issue Date FY: 2022 ( Subtotal = $793,120 )
2022	2022	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	20	8/15/2022	NON-COMPETING CONTINUATION	$793,120
														Subtotal = $793,120

Issue Date FY: 2021 ( Subtotal = $793,120 )
2021	2021	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	19	8/31/2021	NON-COMPETING CONTINUATION	$793,120
														Subtotal = $793,120

Issue Date FY: 2020 ( Subtotal = $825,474 )
2020	2020	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	18	9/3/2020	COMPETING CONTINUATION	$825,474
														Subtotal = $825,474

Grand Total All Awards = $4,882,608

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Towards Curative Therapies for Hypogonadotropic Diseases

Award Number: R37HD043341

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2003

PERIOD OF PERFORMANCE END DATE: 08/31/2025

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