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Mechanistic insights into LSD actions at 5-HT2A serotonin receptors

Award Number: R37DA045657
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2023
PERIOD OF PERFORMANCE END DATE: 02/29/2028

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Mechanistic insights into LSD actions at 5-HT2A serotonin receptors - Psychedelic drugs continue to be used and abused by large numbers of individuals within the US and recently there has been a resurgence of interest in the actions of psychedelic drugs like lysergic acid diethylamide (LSD). It is currently unknown how LSD and related psychedelic drugs exert their actions at the molecular and atomic levels. In this MERIT extension we will elucidate the molecular mechanisms by which LSD and related drugs interact with multiple G protein coupled receptors. We will also determine the potential relevance of differences between human and rodent receptors for the actions of LSD and related drugs in vitro and in vivo. Finally we will examine the effects of LSD and related drugs on the gene transcriptional changes which occur specifically in neurons which express receptor essential for the actions of LSD. Taken together, these new findings will provide molecular and atomic details regading the actions of psychedelic drugs in vitro and in vivo.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $650,756 )
2025	2025	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Drug Use and Addiction Research Programs	000	8	2/14/2025	NON-COMPETING CONTINUATION	$585,680
2025	2025	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Drug Use and Addiction Research Programs	001	8	4/10/2025	NON-COMPETING CONTINUATION	$65,076
														Subtotal = $650,756

Issue Date FY: 2024 ( Subtotal = $650,756 )
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Drug Use and Addiction Research Programs	001	7	4/25/2024	NON-COMPETING CONTINUATION	$65,076
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Drug Use and Addiction Research Programs	000	7	2/15/2024	NON-COMPETING CONTINUATION	$585,680
2024	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Drug Use and Addiction Research Programs	003	6	4/29/2024	EXTENSION WITH OR WITHOUT FUNDS	$97,798
2024	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Drug Use and Addiction Research Programs	002	5	4/29/2024	NON-COMPETING CONTINUATION	-$97,798
														Subtotal = $650,756

Issue Date FY: 2023 ( Subtotal = $664,506 )
2023	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Drug Use and Addiction Research Programs	000	6	3/2/2023	EXTENSION WITH OR WITHOUT FUNDS	$664,506
														Subtotal = $664,506

Issue Date FY: 2022 ( Subtotal = $639,458 )
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Drug Use and Addiction Research Programs	001	5	3/21/2022	NON-COMPETING CONTINUATION	$63,949
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Drug Use and Addiction Research Programs	000	5	2/18/2022	NON-COMPETING CONTINUATION	$575,509
														Subtotal = $639,458

Issue Date FY: 2021 ( Subtotal = $635,456 )
2021	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Drug Use and Addiction Research Programs	000	4	2/19/2021	NON-COMPETING CONTINUATION	$635,456
														Subtotal = $635,456

Issue Date FY: 2020 ( Subtotal = $635,456 )
2020	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Drug Use and Addiction Research Programs	000	3	2/21/2020	NON-COMPETING CONTINUATION	$635,456
														Subtotal = $635,456

Issue Date FY: 2019 ( Subtotal = $634,832 )
2019	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Drug Use and Addiction Research Programs	000	2	2/12/2019	NON-COMPETING CONTINUATION	$634,832
														Subtotal = $634,832

Issue Date FY: 2018 ( Subtotal = $646,833 )
2018	2018	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Drug Use and Addiction Research Programs	001	1	6/27/2018	NEW	$1,254
2018	2018	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Drug Use and Addiction Research Programs	002	1	9/13/2018	NEW	$0
2018	2018	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Drug Use and Addiction Research Programs	000	1	3/2/2018	NEW	$645,579
														Subtotal = $646,833

Grand Total All Awards = $5,158,053

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Mechanistic insights into LSD actions at 5-HT2A serotonin receptors

Award Number: R37DA045657

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2023

PERIOD OF PERFORMANCE END DATE: 02/29/2028

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