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Air Pollution and Neighborhood Stressors as Determinants of Non-Small Cell Lung Cancer (NSCLC) Mutation Patterns and Recurrence

Award Number: R37CA284040
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/10/2024
PERIOD OF PERFORMANCE END DATE: 04/30/2029

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Air Pollution and Neighborhood Stressors as Determinants of Non-Small Cell Lung Cancer (NSCLC) Mutation Patterns and Recurrence - Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related death in the United States. Certain populations, such as non-Hispanic Black/African American (AA) individuals, are diagnosed at younger ages and experience less favorable outcomes. AA communities are also exposed to higher levels of environmental pollutants such as fine particulate matter (PM2.5). This study will investigate how long-term exposure to air pollution and neighborhood-level environmental stressors—including poverty indicators and limited access to resources—contributes to mutational patterns and disease progression in early-stage NSCLC in a high-risk population. We hypothesize that cumulative exposure to these stressors influences the timing and type of somatic mutations, ultimately affecting recurrence risk. We will conduct a study of 300 AA patients with stage I–II NSCLC from California, Georgia, and Detroit, integrating whole-genome sequencing (WGS) of tumor tissue with individualized environmental and geospatial exposure data. The aims of the study are to: (1) identify relationships between exposure history and mutational signatures (order and types of mutations); (2) assess how these exposures influence early recurrence (within 2 years post-surgery); and (3) compare the tumor genomics of never-smoking AA patients to the national Sherlock-Lung study, to evaluate the modifying effect of environmental stressors. This research will generate insights into how external exposures influence NSCLC biology and outcomes and may inform risk stratification and early detection strategies tailored to individuals experiencing elevated environmental exposures.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,190,046 )
2025	2025	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	000	2	7/17/2025	NON-COMPETING CONTINUATION	$1,190,046
														Subtotal = $1,190,046

Issue Date FY: 2024 ( Subtotal = $1,027,816 )
2024	2024	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	000	1	5/13/2024	NEW	$1,027,816
														Subtotal = $1,027,816

Grand Total All Awards = $2,217,862

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Air Pollution and Neighborhood Stressors as Determinants of Non-Small Cell Lung Cancer (NSCLC) Mutation Patterns and Recurrence

Award Number: R37CA284040

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/10/2024

PERIOD OF PERFORMANCE END DATE: 04/30/2029

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