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An inoculation theory-based messaging intervention addressing misinformation about HPV vaccine on social media: The Inoculate for HPV Vaccine randomized controlled trial

Award Number: R37CA259210
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/12/2022
PERIOD OF PERFORMANCE END DATE: 04/02/2025
AWARD TERMINATION DATE: 04/05/2025

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An inoculation theory-based messaging intervention addressing misinformation about HPV vaccine on social media: The Inoculate for HPV Vaccine randomized controlled trial - Project Summary Background: Misinformation on social media, or the sharing of false or incomplete information without intent to cause harm, is contributing to vaccine hesitancy among parents and impeding uptake of the HPV vaccine among adolescents in the United States. Innovative communication strategies that can be rapidly developed and deployed to correct evolving misinformation about HPV vaccine on social media and increase uptake of HPV vaccine are needed. Hypothesis: We hypothesize that theory-based corrective messages directly addressing the content of misinformation will improve HPV vaccine series initiation and completion as compared to general corrective messages and a non-message control group. Proposal: We will efficiently identify recently circulating misinformation on social media using natural language processing (NLP) methods, develop and test a theory-based corrective messaging tool using a validated message testing protocol, and assess the efficacy of the tool on increasing HPV vaccine series initiation and completion among adolescents in an online, block-randomized controlled trial with three arms and longitudinal follow-up. Participants (n=2500) will be parents of adolescents ages 8-11 recruited from social media and followed up over a 12-month period. Importance and Innovation: If successful, in addition to improving HPV vaccination uptake, the methods from this study have the potential to be adapted to address other forms of misinformation swiftly and efficiently in public health such as that surrounding COVID19, childhood vaccinations, or cancer prevention and treatment strategies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$90,775 )
2026	2025	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT STREET	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Cause and Prevention Research	000	4	11/28/2025	TERMINATION	-$90,775
														Subtotal = -$90,775

Issue Date FY: 2025 ( Subtotal = $1 )
2025	2025	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Cause and Prevention Research	000	4	3/14/2025	NON-COMPETING CONTINUATION	$548,283
2025	2025	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Cause and Prevention Research	001	4	4/4/2025	TERMINATION	-$548,282
														Subtotal = $1

Issue Date FY: 2024 ( Subtotal = $592,790 )
2024	2024	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Cause and Prevention Research	000	3	4/24/2024	NON-COMPETING CONTINUATION	$592,790
														Subtotal = $592,790

Issue Date FY: 2023 ( Subtotal = $632,904 )
2023	2023	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Cause and Prevention Research	000	2	3/22/2023	NON-COMPETING CONTINUATION	$632,904
														Subtotal = $632,904

Issue Date FY: 2022 ( Subtotal = $677,727 )
2022	2022	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Cause and Prevention Research	000	1	4/12/2022	NEW	$677,727
														Subtotal = $677,727

Grand Total All Awards = $1,812,647

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An inoculation theory-based messaging intervention addressing misinformation about HPV vaccine on social media: The Inoculate for HPV Vaccine randomized controlled trial

Award Number: R37CA259210

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/12/2022

PERIOD OF PERFORMANCE END DATE: 04/02/2025

AWARD TERMINATION DATE: 04/05/2025

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