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Reduction of Tumor-Positive Margins in Oncology Surgery

Award Number: R37CA245157
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2021
PERIOD OF PERFORMANCE END DATE: 04/30/2026

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Reduction of Tumor-Positive Margins in Oncology Surgery - Project Abstract Approximately 80% of early stage head and neck tumors undergo surgery of curative intent at some point in their treatment course. The success of this oncologic surgery primarily depends on obtaining clear surgical margins. Despite best efforts to obtain wide margins, the surgeon always struggles with removal of healthy, functional tissue. This resulting tension often results in close (<5mm) or positive (tumor at cut surface) margins in 30% of head and neck cancer resections. We have developed a strategy that could improve both intraoperative and ex vivo margin assessment using a fluorescently labeled therapeutic antibody as a targeted imaging agent. We hypothesize that fluorescence imaging of a systemically injected fluorescent anti-epidermal growth factor receptor (EGFR) antibody (EGFR is over-expressed in 80-90% patients with head and neck cancer) will direct the attention of the surgeon and pathologist toward areas that are more likely to be tumor-positive and reduce sampling error. This will lead to improved identification of tumor-positive margins, and thus improved surgical outcome. 1


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $509,844 )
2025	2025	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Treatment Research	000	5	4/1/2025	NON-COMPETING CONTINUATION	$458,861
2025	2025	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Treatment Research	001	5	5/29/2025	NON-COMPETING CONTINUATION	$50,983
														Subtotal = $509,844

Issue Date FY: 2024 ( Subtotal = $517,409 )
2024	2024	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Treatment Research	000	4	4/8/2024	NON-COMPETING CONTINUATION	$517,409
														Subtotal = $517,409

Issue Date FY: 2023 ( Subtotal = $538,275 )
2023	2023	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Treatment Research	000	3	4/25/2023	NON-COMPETING CONTINUATION	$538,275
														Subtotal = $538,275

Issue Date FY: 2022 ( Subtotal = $547,188 )
2022	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Treatment Research	000	2	5/2/2022	NON-COMPETING CONTINUATION	$547,188
														Subtotal = $547,188

Issue Date FY: 2021 ( Subtotal = $563,251 )
2021	2021	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Treatment Research	000	1	4/22/2021	NEW	$563,251
														Subtotal = $563,251

Grand Total All Awards = $2,675,967

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Reduction of Tumor-Positive Margins in Oncology Surgery

Award Number: R37CA245157

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2021

PERIOD OF PERFORMANCE END DATE: 04/30/2026

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