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Determining the impact of cannabis use and severity on tobacco cessation outcomes: A prospective tobacco treatment trial

Award Number: R37CA237245
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2019
PERIOD OF PERFORMANCE END DATE: 08/31/2026

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Determining the impact of cannabis use and severity on tobacco cessation outcomes: A prospective tobacco treatment trial - PROJECT SUMMARY/ABSTRACT This proposal is in response to PAR-21-138: Method to Extend Research in Time (MERIT) Award Extension Request, which includes a 2-year MERIT extension request to support new data collection focused on cannabis-tobacco co-use and the implications of cannabis use on tobacco cessation outcomes. This MERIT proposal represents a timely and logical extension of the NCI-funded parent MERIT award (R37 CA237245, PI McClure) entitled, “Determining the impact of cannabis use and severity on tobacco cessation outcomes: A prospective tobacco treatment trial.” The overall goal of the funded parent R37 MERIT award was to conduct a prospective tobacco treatment study evaluating the impact of cannabis co-use on tobacco cessation outcomes, focused specifically on those smoking cigarettes. In the parent study, participants who co-use cigarettes and cannabis are being oversampled 2:1 to cigarette-only participants. The parent study is designed to evaluate how cannabis use may serve as a barrier to successful tobacco cessation and how cannabis use changes during a tobacco cessation attempt. Several important observations have emerged during the course of the parent award as well as in the tobacco-cannabis co-use literature more broadly, prompting the proposed 2-year MERIT extension. Specifically, the use of e-cigarettes (vaped nicotine products; electronic nicotine delivery systems [ENDS]) has increased among youth and adults in the United States (US). These trends in non-combustible forms of tobacco use have been observed in the parent R37 award. Within the parent study, we are excluding a large number of interested callers due to their use of e-cigarettes primarily or in combination with cigarettes at a frequency that is exclusionary. While the parent study is focused on combustible tobacco use (cigarette smoking), which is the most harmful of tobacco products, the ubiquity of e-cigarettes cannot be ignored, particularly as it relates to cessation and the underlying relationship with cannabis co-use. Therefore, this 2-year MERIT extension proposes to enroll a third group of adults (ages 18-40; N=70) who are using e-cigarettes daily or near daily (co-use of cigarettes is allowable; <10 days out of the past 30) and are also using cannabis. We will leverage the methods, measures, and procedures being used as part of the parent R37 to complete this e- cigarette cessation trial with a focus on a co-use population to extend the generalizability of study findings. The sample of e-cigarette-cannabis co-use participants is the main difference in this MERIT extension. This 2-year MERIT extension will allow for the exploration of e-cigarette and cannabis co-use characteristics and the impact of cannabis co-use on e-cigarette cessation. New data collection proposed here falls within the scope of the parent grant and represents an important extension of the original aims. The inclusion of those using tobacco through both cigarettes and e-cigarettes will allow for the evaluation of cannabis co-use on tobacco/nicotine cessation and changes in the relationship between substances during a quit attempt.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $580,584 )
2025	2025	THE MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Cause and Prevention Research	001	7	8/11/2025	NON-COMPETING CONTINUATION	$580,584
2025	2023	THE MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Cause and Prevention Research	000	5	2/28/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $580,584

Issue Date FY: 2024 ( Subtotal = $558,891 )
2024	2024	THE MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Cause and Prevention Research	000	6	9/20/2024	EXTENSION WITH OR WITHOUT FUNDS	$558,891
														Subtotal = $558,891

Issue Date FY: 2023 ( Subtotal = $592,830 )
2023	2023	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Cause and Prevention Research	000	5	6/28/2023	NON-COMPETING CONTINUATION	$592,830
														Subtotal = $592,830

Issue Date FY: 2022 ( Subtotal = $680,725 )
2022	2022	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Cause and Prevention Research	001	4	9/12/2022	SUPPLEMENT FOR EXPANSION	$75,500
2022	2022	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Cause and Prevention Research	000	4	6/23/2022	NON-COMPETING CONTINUATION	$605,225
														Subtotal = $680,725

Issue Date FY: 2021 ( Subtotal = $605,001 )
2021	2021	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Cause and Prevention Research	000	3	6/14/2021	NON-COMPETING CONTINUATION	$605,001
														Subtotal = $605,001

Issue Date FY: 2020 ( Subtotal = $605,272 )
2020	2020	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Cause and Prevention Research	000	2	6/5/2020	NON-COMPETING CONTINUATION	$605,272
														Subtotal = $605,272

Issue Date FY: 2019 ( Subtotal = $605,056 )
2019	2019	MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Cause and Prevention Research	000	1	6/24/2019	NEW	$605,056
														Subtotal = $605,056

Grand Total All Awards = $4,228,359

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Determining the impact of cannabis use and severity on tobacco cessation outcomes: A prospective tobacco treatment trial

Award Number: R37CA237245

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2019

PERIOD OF PERFORMANCE END DATE: 08/31/2026

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