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Mechanisms that Regulate Antibody Class Switch Recombination and Somatic Hypermutation

Award Number: R37AI077595
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/15/2008
PERIOD OF PERFORMANCE END DATE: 03/31/2029

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Mechanisms that Regulate Antibody Class Switch Recombination and Somatic Hypermutation - Project Summary/Abstract of Research Plans for the Extension Period The first two specific aims of this R37 grant were to test our hypothesis that cohesin-mediated loop extrusion plays a key role in lgH class switch recombination (CSR) and lg variable region exon somatic hypermutation (SHM). A third aim was to test our hypothesis that Peyer's Patch (PP) germinal centers(GCs) expand rare V(D)J clonotypes with high intrinsic SHM levels. For these studies, we developed powerful assays for CSR, SHM and chromatin interactions. We also employed our RAG2-defcient blastocyst complementation approach (RDBC) to generate ES cell-based V(D)J passenger allele and V(D)J-rearranging mouse models for in vivo studies. Despite pandemic challenges, we made substantial progress in the first 3.5 years.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $637,200 )
2026	2026	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	18	4/1/2026	NON-COMPETING CONTINUATION	$637,200
														Subtotal = $637,200

Issue Date FY: 2025 ( Subtotal = $637,200 )
2025	2025	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	17	2/12/2025	NON-COMPETING CONTINUATION	$637,200
2025	2023	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	001	15	2/19/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $637,200

Issue Date FY: 2024 ( Subtotal = $637,200 )
2024	2024	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	002	16	5/15/2024	EXTENSION WITH OR WITHOUT FUNDS	$63,720
2024	2024	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	001	16	2/16/2024	EXTENSION WITH OR WITHOUT FUNDS	$0
2024	2024	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	16	1/24/2024	EXTENSION WITH OR WITHOUT FUNDS	$573,480
														Subtotal = $637,200

Issue Date FY: 2023 ( Subtotal = $531,000 )
2023	2023	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	15	5/1/2023	NON-COMPETING CONTINUATION	$531,000
														Subtotal = $531,000

Issue Date FY: 2022 ( Subtotal = $531,000 )
2022	2022	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	14	4/21/2022	NON-COMPETING CONTINUATION	$531,000
														Subtotal = $531,000

Issue Date FY: 2021 ( Subtotal = $531,000 )
2021	2021	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	13	4/14/2021	NON-COMPETING CONTINUATION	$531,000
														Subtotal = $531,000

Issue Date FY: 2020 ( Subtotal = $531,000 )
2020	2020	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	12	3/20/2020	NON-COMPETING CONTINUATION	$531,000
														Subtotal = $531,000

Issue Date FY: 2019 ( Subtotal = $553,634 )
2019	2019	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	001	11	6/18/2019	COMPETING CONTINUATION	$0
2019	2019	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	003	11	9/23/2019	COMPETING CONTINUATION	$22,634
2019	2019	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	002	11	6/20/2019	COMPETING CONTINUATION	$0
2019	2019	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	11	5/24/2019	COMPETING CONTINUATION	$531,000
														Subtotal = $553,634

Grand Total All Awards = $4,589,234

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Mechanisms that Regulate Antibody Class Switch Recombination and Somatic Hypermutation

Award Number: R37AI077595

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/15/2008

PERIOD OF PERFORMANCE END DATE: 03/31/2029

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