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Human Cerebellar Function in Multiple Task Domains

Award Number: R35NS116883
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2020
PERIOD OF PERFORMANCE END DATE: 04/30/2028

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Human Cerebellar Function in Multiple Task Domains - PROJECT SUMMARY The goal of this project is to extend our understanding of the cerebellum, and in particular, how this subcortical structure contributes to human cognition. Diverse lines of research provide compelling evidence that the cerebellum is not only involved in sensorimotor control, but also contributes to a range of cognitive functions. For example, the neuroimaging literature has produced maps of the cerebellum that exhibit a stable functional organization, with much of the cerebellar cortex showing hemodynamic changes that cannot be attributed to movement. Moreover, patients with cerebellar disorders exhibit behavioral impairments on tasks assessing cognitive and affective processing. However, our understanding of the functional role of the cerebellum in cognitive domains remains rudimentary: Functional hypotheses have either been largely descriptive or targeted to account for cerebellar function in a relatively narrow, task-specific manner. The research program outlined in this proposal is designed to address this issue, seeking to develop a mechanistic account of cerebellar function. Theoretically, the work will be guided by a novel hypothesis, namely that the cerebellum is essential for processing that requires the continuous transformation of an internal representation, or CoRT(continuous representational transformation). This hypothesis offers a parsimonious account of how the cerebellum supports performance in diverse task domains. In the context of sensorimotor control, CoRT would entail computations required to move a limb from one position to another and to anticipate the sensory consequences of that movement. In other task domains, the continuous transformation of an internal representation may optimize anticipatory behavior; for example, perception frequently involves the internal transformation of the sensory input to account for atypical viewpoints, and social judgments may benefit continuously simulating the intended actions of another individual. The research program will involve the integrated use of behavioral, computational, and neuroimaging studies. One major component of the behavioral work will focus on the performance of individuals with spinocerebellar ataxia (SCA). This work will involve traditional on-site experiments spanning a broad range of task domains to test the CoRT hypothesis, as well as an ambitious on-line testing program. Through an outreach program facilitated by SCA support networks and collaborations with an international team of researchers, the on-line program should produce a unique database to provide well-powered tests of functional hypotheses, and examine relationships between behavioral performance, etiology, and clinical ratings, and relate these measures with region-specific pathology in the cerebellum. A second major component will build on recent neuroimaging work with healthy young adults that has provided a comprehensive functional map of the human cerebellum though the use of a large battery of tasks. This approach will be used to explore constraints on the organization of the functional map by developing models of cortico-cerebellar connectivity and examining changes over the course of learning. As with the neuropsychological studies, the neuroimaging studies will yield a rich database to evaluate different functional hypotheses, as well as establish norms for comparison with atypical populations. !


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $720,199 )
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	119 CALIFORNIA HALL	BERKELEY	CA	94720	ALAMEDA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	7	4/29/2026	NON-COMPETING CONTINUATION	$720,199
2026	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	6	1/29/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $720,199

Issue Date FY: 2025 ( Subtotal = $817,890 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	6	8/22/2025	SUPPLEMENT FOR EXPANSION	$97,691
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	6	7/17/2025	NON-COMPETING CONTINUATION	$720,199
														Subtotal = $817,890

Issue Date FY: 2024 ( Subtotal = $796,284 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	5	8/2/2024	NON-COMPETING CONTINUATION	$0
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	6/17/2024	SUPPLEMENT FOR EXPANSION	$97,691
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	6/14/2024	NON-COMPETING CONTINUATION	$698,593
														Subtotal = $796,284

Issue Date FY: 2023 ( Subtotal = $805,751 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	4	7/17/2023	SUPPLEMENT FOR EXPANSION	$85,552
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	5/25/2023	NON-COMPETING CONTINUATION	$720,199
														Subtotal = $805,751

Issue Date FY: 2022 ( Subtotal = $720,199 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	5/19/2022	NON-COMPETING CONTINUATION	$720,199
														Subtotal = $720,199

Issue Date FY: 2021 ( Subtotal = $720,199 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	4/6/2021	NON-COMPETING CONTINUATION	$720,199
														Subtotal = $720,199

Issue Date FY: 2020 ( Subtotal = $709,988 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	4/21/2020	NEW	$709,988
														Subtotal = $709,988

Grand Total All Awards = $5,290,510

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Human Cerebellar Function in Multiple Task Domains

Award Number: R35NS116883

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2020

PERIOD OF PERFORMANCE END DATE: 04/30/2028

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