Monday, June 30, 2025 6/30/2025

Uncovering the Neural Mechanisms that Flexibly Link Sensory Processing to Behavior

Award Number: R35NS111580
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2019
PERIOD OF PERFORMANCE END DATE: 04/30/2027

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Uncovering the Neural Mechanisms that Flexibly Link Sensory Processing to Behavior - Over the past eight years, my lab has pioneered studies of the acoustic communication system of Drosophila, to address fundamental questions related to the neural mechanisms underlying sensory perception and the generation of behaviors. Similar to other animals, flies produce and process patterned sounds during their mating ritual. Using a combination of novel behavioral assays, neural circuit perturbations, neural recordings, and computational modeling, we discovered that male song structure and intensity are continually sculpted by interactions with the female, over timescales ranging from tens of milliseconds to minutes. Building on this finding, we have gone on to dissect the neural mechanisms underlying the visual modulation of song patterning in males. Using a similar set of tools, we have also interrogated the female side of acoustic communication, and have successfully related song representations along the auditory pathway to changes in locomotor behavior, again across multiple timescales. My lab has developed several new methods to facilitate these studies, including methods for tracking and segmenting animal behavior, for population neural imaging, and for single-cell transcriptomics in the Drosophila brain. Our system and discoveries lay the essential foundation for now solving the bigger challenge of how an animal's internal state and experiences contribute to shaping these neural mechanisms. To do so, we will employ new computational models to identify the neural correlates of internal state. We will also use a new paradigm to induce learning during acoustic communication, and will characterize how learning shapes sensorimotor integration in this system. Finally, we will manipulate the hunger or arousal status of flies to determine, again at the cellular level, how long timescale modulation of neural activity shapes fast timescale sensorimotor processes. These new research directions will leverage the methods we have optimized for the recording and analysis of neural and behavioral data, in addition to incorporating new methods for recording activity in behaving flies that experience naturalistic, multimodal courtship stimuli timed to their movements on a spherical treadmill. What we discover in this system will reveal fundamental principles regarding how brains mediate perceptions, thoughts, actions, and ultimately the ability to communicate with another individual.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $739,450 )
2025	2025	THE TRUSTEES OF PRINCETON UNIVERSITY	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	7	6/10/2025	SUPPLEMENT FOR EXPANSION	$164,000
2025	2025	THE TRUSTEES OF PRINCETON UNIVERSITY	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	7	5/13/2025	NON-COMPETING CONTINUATION	$575,450
														Subtotal = $739,450

Issue Date FY: 2024 ( Subtotal = $721,853 )
2024	2024	THE TRUSTEES OF PRINCETON UNIVERSITY	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	6	6/11/2024	NON-COMPETING CONTINUATION	$558,188
2024	2024	THE TRUSTEES OF PRINCETON UNIVERSITY	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	6	8/9/2024	SUPPLEMENT FOR EXPANSION	$163,665
														Subtotal = $721,853

Issue Date FY: 2023 ( Subtotal = $575,450 )
2023	2023	THE TRUSTEES OF PRINCETON UNIVERSITY	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	5/15/2023	NON-COMPETING CONTINUATION	$575,450
														Subtotal = $575,450

Issue Date FY: 2022 ( Subtotal = $575,450 )
2022	2022	TRUSTEES OF PRINCETON UNIVERSITY, THE	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	5/27/2022	NON-COMPETING CONTINUATION	$575,450
														Subtotal = $575,450

Issue Date FY: 2021 ( Subtotal = $575,450 )
2021	2021	TRUSTEES OF PRINCETON UNIVERSITY, THE	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	4/22/2021	NON-COMPETING CONTINUATION	$575,450
														Subtotal = $575,450

Issue Date FY: 2020 ( Subtotal = $575,450 )
2020	2020	TRUSTEES OF PRINCETON UNIVERSITY, THE	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	5/28/2020	NON-COMPETING CONTINUATION	$575,450
														Subtotal = $575,450

Issue Date FY: 2019 ( Subtotal = $494,450 )
2019	2019	TRUSTEES OF PRINCETON UNIVERSITY, THE	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	5/1/2019	NEW	$494,450
														Subtotal = $494,450

Grand Total All Awards = $4,257,553

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Uncovering the Neural Mechanisms that Flexibly Link Sensory Processing to Behavior

Award Number: R35NS111580

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2019

PERIOD OF PERFORMANCE END DATE: 04/30/2027

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