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Neural Control of Breathing

Award Number: R35HL171451
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/12/2024
PERIOD OF PERFORMANCE END DATE: 01/31/2031

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Neural Control of Breathing - PROJECT SUMMARY/ ABSTRACT Breathing is a remarkable behavior fundamental to life that mediates gas exchange to support metabolism and regulate pH. A reliable, non-stop, robust rhythmic pattern of respiratory muscle activity is essential for breathing in mammals. Failure to maintain a normal breathing pattern in humans suffering from sleep apnea, apnea of prematurity, congenital central hypoventilation syndrome, hyperventilation syndrome, Rett syndrome, and perhaps Sudden Infant Death Syndrome, leads to serious adverse health consequences, even death. Various neuro- degenerative diseases, such as Parkinson's disease, multiple systems atrophy, and amyotrophic lateral sclerosis, are associated with sleep disordered breathing that appear to result from the loss of neurons in brain areas controlling breathing. If breathing is to be understood in normal and in pathological conditions, the mechanisms for breathing central pattern generation must be revealed. We focus on two brainstem sites essential for generation of the normal breathing pattern, the preBötzinger Complex and the retrotrapezoid nucleus/parafacial respiratory group. We propose a broad series of experiments both in vivo and in vitro in rodents using state-of-the-art techniques to significantly advance our under- standing of respiratory rhythm and pattern generation to provide an extraordinary window into the mechanisms underlying the neural control of breathing. Such advancements will be foundational for development of highly novel therapies for treating human diseases of breathing.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $979,510 )
2025	2025	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	National Center on Sleep Disorders Research	000	2	4/1/2025	NON-COMPETING CONTINUATION	$979,510
														Subtotal = $979,510

Issue Date FY: 2024 ( Subtotal = $1,088,345 )
2024	2024	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10920 WILSHIRE BLVD STE 500	LOS ANGELES	CA	90024	LOS ANGELES	USA	National Center on Sleep Disorders Research	000	1	2/12/2024	NEW	$1,088,345
2024	2024	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10920 WILSHIRE BLVD STE 500	LOS ANGELES	CA	90024	LOS ANGELES	USA	National Center on Sleep Disorders Research	001	1	3/4/2024	NEW	$0
														Subtotal = $1,088,345

Grand Total All Awards = $2,067,855

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Neural Control of Breathing

Award Number: R35HL171451

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/12/2024

PERIOD OF PERFORMANCE END DATE: 01/31/2031

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