Wednesday, July 2, 2025 7/2/2025

Cell-cell interactions governing lung epithelial progenitor cells

Award Number: R35HL150876
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/15/2020
PERIOD OF PERFORMANCE END DATE: 01/31/2027

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Cell-cell interactions governing lung epithelial progenitor cells - Summary My lab’s contributions have helped bring lung biology to the forefront of stem cell biology. Our major focus has been to develop tools to characterize progenitor cells in the adult lung and in lung cancer; I now aim to develop this expertise for applications in lung diseases. We created three-dimensional co-culture organoid systems that have begun to define cell-cell crosstalk between epithelial progenitors and other supporting cell types in the lung. We can now model the formation of airway- and alveolar-like structures from lung progenitor cells, and we have a platform to understand differentiation control at the molecular level. This research program seeks to build on our advances and to further develop lung organoids to interrogate the molecular underpinnings of cell-cell interactions between epithelial progenitor cells and their environment in the adult lung homeostasis and in diseased lung. We will determine the signals through which epithelial progenitors are regulated by mesenchymal cells and endothelial cells during lung injury response and repair. Cells from mouse models of lung disease will be used for single cell RNA-sequencing and in organoid systems to identify cell autonomous and paracrine mechanisms that can be used for therapeutic intervention. We will refine our techniques for use with human lung cells. We will create a lung progenitor cell transplantation assay, a critical need in the lung community for the study of progenitors and for regenerative medicine. While other groups are focused on cataloging lung cell types, our strategies will provide essential tools to interrogate the biological functions of diverse lung cells. Collectively, these new approaches will allow us to continue to build and utilize transformative methods to probe numerous aspects of the biology of normal lung and lung disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $796,500 )
2025	2025	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Lung Diseases Research	000	6	3/27/2025	NON-COMPETING CONTINUATION	$796,500
														Subtotal = $796,500

Issue Date FY: 2024 ( Subtotal = $867,300 )
2024	2024	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Lung Diseases Research	001	5	6/21/2024	NON-COMPETING CONTINUATION	$70,800
2024	2024	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Lung Diseases Research	000	5	1/30/2024	NON-COMPETING CONTINUATION	$796,500
														Subtotal = $867,300

Issue Date FY: 2023 ( Subtotal = $885,000 )
2023	2023	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Lung Diseases Research	000	4	2/3/2023	NON-COMPETING CONTINUATION	$885,000
														Subtotal = $885,000

Issue Date FY: 2022 ( Subtotal = $885,000 )
2022	2022	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Lung Diseases Research	001	3	1/31/2022	NON-COMPETING CONTINUATION	$796,499
2022	2022	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Lung Diseases Research	002	3	6/13/2022	NON-COMPETING CONTINUATION	$88,501
2022	2021	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Lung Diseases Research	000	2	10/15/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $885,000

Issue Date FY: 2021 ( Subtotal = $885,000 )
2021	2021	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Lung Diseases Research	000	2	1/22/2021	NON-COMPETING CONTINUATION	$796,500
2021	2021	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Lung Diseases Research	001	2	5/24/2021	NON-COMPETING CONTINUATION	$88,500
														Subtotal = $885,000

Issue Date FY: 2020 ( Subtotal = $885,000 )
2020	2020	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Lung Diseases Research	000	1	3/8/2020	NEW	$885,000
														Subtotal = $885,000

Grand Total All Awards = $5,203,800

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Cell-cell interactions governing lung epithelial progenitor cells

Award Number: R35HL150876

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/15/2020

PERIOD OF PERFORMANCE END DATE: 01/31/2027

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