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Translational Control of Megakaryocyte and Platelet Gene Expression in Disease

Award Number: R35HL145237
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Translational Control of Megakaryocyte and Platelet Gene Expression in Disease - Overall Summary/Abstract This Outstanding Investigator Award R35 program addresses previously-unexplored mechanisms by which regulation of gene expression at the translational level controls the functions of megakaryocytes and platelets, in the setting of health and disease. Studies will employ basic and clinical investigations in humans and mice to comprehensively determine how translational pathways that converge on Eukaryotic Initiation Factor 4E (eIF4E) regulate megakaryocyte and platelet biology. Roles for translational control pathways in megakaryocytes have not previously been studied, their functional significance in circulating platelets is uncertain, and it is unknown how disease situations alter translational responses of megakaryocytes and platelets. Thus, successful completion of the research objectives will fill key gaps in knowledge that need to be addressed in heart, lung, and blood research. Results generated will also determine if translational control pathway inhibitors, which are currently being tested in the clinic, have off-target effects on megakaryocytes and platelets.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $641,012 )
2025	2025	OKLAHOMA MEDICAL RESEARCH FOUNDATION	825 NE 13TH ST	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Blood Diseases and Resources Research	000	7	1/20/2025	NON-COMPETING CONTINUATION	$641,012
														Subtotal = $641,012

Issue Date FY: 2024 ( Subtotal = $697,991 )
2024	2024	OKLAHOMA MEDICAL RESEARCH FOUNDATION	825 NE 13TH ST	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Blood Diseases and Resources Research	000	6	12/14/2023	NON-COMPETING CONTINUATION	$641,012
2024	2024	OKLAHOMA MEDICAL RESEARCH FOUNDATION	825 NE 13TH ST	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Blood Diseases and Resources Research	001	6	6/14/2024	NON-COMPETING CONTINUATION	$56,979
														Subtotal = $697,991

Issue Date FY: 2023 ( Subtotal = $712,236 )
2023	2023	OKLAHOMA MEDICAL RESEARCH FOUNDATION	825 NE 13TH ST	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Blood Diseases and Resources Research	001	5	3/3/2023	NON-COMPETING CONTINUATION	$71,224
2023	2023	OKLAHOMA MEDICAL RESEARCH FOUNDATION	825 NE 13TH ST	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Blood Diseases and Resources Research	000	5	1/12/2023	NON-COMPETING CONTINUATION	$641,012
														Subtotal = $712,236

Issue Date FY: 2022 ( Subtotal = $730,936 )
2022	2022	OKLAHOMA MEDICAL RESEARCH FOUNDATION	825 NE 13TH ST	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Blood Diseases and Resources Research	001	4	4/30/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$717,759
2022	2022	OKLAHOMA MEDICAL RESEARCH FOUNDATION	825 NE 13TH ST	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Blood Diseases and Resources Research	003	4	6/10/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$13,177
2022	2021	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Blood Diseases and Resources Research	000	3	4/30/2022	NON-COMPETING CONTINUATION	$0
2022	2021	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Blood Diseases and Resources Research	002	3	5/12/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $730,936

Issue Date FY: 2021 ( Subtotal = $913,733 )
2021	2021	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Blood Diseases and Resources Research	002	3	8/18/2021	NON-COMPETING CONTINUATION	$0
2021	2021	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Blood Diseases and Resources Research	001	3	5/24/2021	NON-COMPETING CONTINUATION	$91,374
2021	2021	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Blood Diseases and Resources Research	000	3	12/23/2020	NON-COMPETING CONTINUATION	$822,359
														Subtotal = $913,733

Issue Date FY: 2020 ( Subtotal = $702,281 )
2020	2020	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Blood Diseases and Resources Research	000	2	12/25/2019	NON-COMPETING CONTINUATION	$667,166
2020	2020	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Blood Diseases and Resources Research	003	2	3/13/2020	NON-COMPETING CONTINUATION	$35,115
2020	2020	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Blood Diseases and Resources Research	001	2	1/9/2020	NON-COMPETING CONTINUATION	$0
2020	2020	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Blood Diseases and Resources Research	002	2	1/17/2020	NON-COMPETING CONTINUATION	$0
2020	2020	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Blood Diseases and Resources Research	005	2	4/7/2020	NON-COMPETING CONTINUATION	$0
2020	2019	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Blood Diseases and Resources Research	004	1	4/7/2020	NEW	$0
														Subtotal = $702,281

Issue Date FY: 2019 ( Subtotal = $253,797 )
2019	2019	UNIVERSITY OF UTAH, THE	201 S PRESIDENT CIRCLE RM 408	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Blood Diseases and Resources Research	000	1	12/31/2018	NEW	$253,797
														Subtotal = $253,797

Grand Total All Awards = $4,651,986

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Translational Control of Megakaryocyte and Platelet Gene Expression in Disease

Award Number: R35HL145237

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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